Flavonoid Metabolites in Human Urine during Blueberry Anthocyanin Intake

文献类型: 外文期刊

第一作者: Kalt, Wilhelmina

作者: Kalt, Wilhelmina;McDonald, Jane E.;Fillmore, Sherry A. E.;Liu, Yan

作者机构:

关键词: Vaccinium angustifolium;bioavailability;LC-MS;enterohepatic;metabolite;profile

期刊名称:JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY ( 影响因子:5.279; 五年影响因子:5.269 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: The human health benefits of anthocyanins (Anc) and other flavonoids are widely recognized. However, the flavonoid-based urinary metabolites arising in vivo after Anc intake are not well described. Human (n = 17) urine was collected while blueberry juice (BJ) was consumed daily for 28 days and once after a 7 day washout. MS/MS scanning of 664 urine samples for 18 parent Anc (PAnc) and 42 predicted Anc metabolites (AncM) yielded 371 products (i.e., MS/MS X retention time (RT)). Flavonoid-based AncM, which were likely underestimated, were almost 20 times more abundant than PAnc. Together, PAnc and AncM accounted for about 1% of the daily Anc dose. Aglycone forms were >94% of the total. Cluster analysis of the 371 Anc identified about 55 major Anc that contributed about 80% to the total Anc. The abundance of flavonoidbased Anc-derived products in the gastrointestinal tract could contribute to the health benefits of Anc-rich berries.

分类号: R15`S

  • 相关文献

[1]Anthocyanin Metabolites Are Abundant and Persistent in Human Urine. Kalt, Wilhelmina,McDonald, Jane E.,Vinqvist-Tymchuk, Melinda R.,Fillmore, Sherry A. E.,Liu, Yan.

[2]Metabolomics Investigation of an Association of Induced Features and Corresponding Fungus during the Co-culture of Trametes versicolor and Ganoderma applanatum. Xu, Xiao-Yan,Shen, Xiao-Ting,Yuan, Xiao-Jie,Zhu, Li-Ping,Yang, Song,Zhou, Yuan-Ming,Fan, Huan,Du, Feng-Yu,Sadilek, Martin,Yang, Jie,Qiao, Bin,Yang, Song. 2018

[3]Phylogenetic Analysis and Expression Patterns of the MAPK Gene Family in Wheat (Triticum aestivum L.). Lian Wei-wei,Tang Yi-miao,Gao Shi-qing,Zhang Zhao,Zhao Xin,Zhao Chang-ping,Lian Wei-wei. 2012

[4]Identification and characterization of microRNAs in the pancreatic fluke Eurytrema pancreaticum. Xu, Min-Jun,Huang, Si-Yang,Fu, Jing-Hua,Zhou, Dong-Hui,Zhu, Xing-Quan,Wang, Chun-Ren,Chang, Qiao-Cheng,Zheng, Xu,Zhu, Xing-Quan,Fu, Jing-Hua,Zhu, Xing-Quan. 2013

[5]Polychlorinated Dibenzo-p-dioxin And Dibenzofurans (pcdd/fs), Polybrominated Diphenyl Ethers (pbdes), And Polychlorinated Biphenyls (pcbs) Monitored By Tree Bark In An E-waste Recycling Area. Wen, Sheng,Yang, F.,Zhang, X. L.,Hui, Y.,Xu, Ying,Wen, Sheng,Li, J. G.,Wu, Y. N.,Zhao, Y. F.,Gong, Yan.

[6]Characterization and evaluation of major anthocyanins in pomegranate (Punica granatum L.) peel of different cultivars and their development phases. Zhao, Xueqing,Fang, Yanming,Zhao, Xueqing,Yuan, Zhaohe,Yin, Yanlei,Feng, Lijuan. 2013

[7]Sensitive Determination of Eight Paralytic Shellfish Poisoning Toxins in Aquatic Products by LC-MS-MS method. Feng Bing,Cai Youqiong,Zhang Xiaoling,Yu Huijuan. 2013

[8]Comparative metabolomics in vanilla pod and vanilla bean revealing the biosynthesis of vanillin during the curing process of vanilla. Gu, Fenglin,Hong, Yinghua,Fang, Yiming,Tan, Lehe,Chen, Yonggan,Gu, Fenglin,Fang, Yiming,Tan, Lehe. 2017

[9]Nontargeted Analysis Using Ultraperformance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry Uncovers the Effects of Harvest Season on the Metabolites and Taste Quality of Tea (Camellia sinensis L.). Dai, Weidong,Qi, Dandan,Yang, Ting,Lv, Haipeng,Guo, Li,Zhang, Yue,Zhu, Yin,Peng, Qunhua,Xie, Dongchao,Tan, Junfeng,Lin, Zhi.

[10]Characterization and Online Detection of Surfactin Isomers Based on HPLC-MSn Analyses and Their Inhibitory Effects on the Overproduction of Nitric Oxide and the Release of TNF-alpha and IL-6 in LPS-Induced Macrophages. Tang, Jin-Shan,Gao, Hao,Dai, Yi,Yao, Zhi-Hong,Ye, Wen-Cai,Yao, Xin-Sheng,Zhao, Feng,Gao, Hao,Li, Jia,Hong, Kui,Li, Jia. 2010

[11]Rapid Metabolite Discovery, Identification, and Accurate Comparison of the Stereoselective Metabolism of Metalaxyl in Rat Hepatic Microsomes. Wang, Xinru,Zhang, Ping,Wang, Yao,Zhou, Zhigiang,Zhu, Wentao,Qiu, Jing,Xu, Peng.

[12]In-tube solid-phase microextraction based on hybrid silica monolith coupled to liquid chromatography-mass spectrometry for automated analysis of ten antidepressants in human urine and plasma. Zheng, Ming-Ming,Wang, Shao-Ting,Hu, Wei-Kang,Feng, Yu-Qi,Zheng, Ming-Ming.

[13]Comprehensive Lipidome-Wide Profiling Reveals Dynamic Changes of Tea Lipids during Manufacturing Process of Black Tea. Li, Jia,Hua, Jinjie,Dong, Chunwang,Wang, Jinjin,Deng, Yuliang,Yuan, Haibo,Jiang, Yongwen,Zhou, Qinghua. 2017

[14]Metabolomic analysis reveals the composition differences in 13 Chinese tea cultivars of different manufacturing suitabilities. Li, Pengliang,Dai, Weidong,Xie, Dongchao,Tan, Junfeng,Yang, Chen,Zhu, Yin,Lv, Haipeng,Peng, Qunhua,Zhang, Yue,Guo, Li,Lin, Zhi,Li, Pengliang,Ni, Dejiang,Lu, Meiling,Li, Pengliang. 2018

[15]Behaviour of spirotetramat residues and its four metabolites in citrus marmalade during home processing. Liu, Yanyu,Chen, Weijun,Sun, Dali,Gong, Lei,Jiang, Liyan,Jiao, Bining,Liu, Yanyu,Chen, Weijun,Sun, Dali,Gong, Lei,Jiang, Liyan,Jiao, Bining,Su, Xuesu,Jian, Qiu,Chen, Weijun,Jiao, Bining,Jiao, Bining.

[16]Study of the dynamic changes in the non-volatile chemical constituents of black tea during fermentation processing by a non-targeted metabolomics approach. Tan, Junfeng,Dai, Weidong,Lv, Haipeng,Guo, Li,Zhang, Yue,Zhu, Yin,Peng, Qunhua,Lin, Zhi,Lu, Meiling.

[17]Gamma irradiation-induced sulfadiazine degradation and its removal mechanisms. Guo, Zhaobing,Zhou, Fei,Zhang, Chaozhi,Liu, Fengling,Bao, Chunxiao,Lin, Mingyue,Guo, Zhaobing,Zhou, Fei,Zhang, Chaozhi,Liu, Fengling,Bao, Chunxiao,Lin, Mingyue,Zhao, Yongfu.

[18]Citrinin Determination in Red Fermented Rice Products by Optimized Extraction Method Coupled to Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS). Ji, Xiaofeng,Xu, Junfeng,Wang, Xiaofu,Qi, Peipei,Wei, Wei,Chen, Xiaoyun,Li, Rui,Zhou, Yu.

[19]Evaluation of tricin, a stylet probing stimulant of brown planthopper, in infested and non-infested rice plants. Zhang, Z.,Li, Y.,Xiao, H.,Li, Y.,Zhang, Y.,Cui, B.,Yan, S..

[20]Nontargeted Modification-Specific Metabolomics Investigation of Glycosylated Secondary Metabolites in Tea (Camellia sinensis L.) Based on Liquid Chromatography-High-Resolution Mass Spectrometry. Dai, Weidong,Tan, Junfeng,Xie, Dongchao,Li, Pengliang,Lv, Haipeng,Zhu, Yin,Guo, Li,Zhang, Yue,Peng, Qunhua,Lin, Zhi,Lu, Meiling.

作者其他论文 更多>>