Flavonoid Metabolites in Human Urine during Blueberry Anthocyanin Intake
文献类型: 外文期刊
第一作者: Kalt, Wilhelmina
作者: Kalt, Wilhelmina;McDonald, Jane E.;Fillmore, Sherry A. E.;Liu, Yan
作者机构:
关键词: Vaccinium angustifolium;bioavailability;LC-MS;enterohepatic;metabolite;profile
期刊名称:JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY ( 影响因子:5.279; 五年影响因子:5.269 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: The human health benefits of anthocyanins (Anc) and other flavonoids are widely recognized. However, the flavonoid-based urinary metabolites arising in vivo after Anc intake are not well described. Human (n = 17) urine was collected while blueberry juice (BJ) was consumed daily for 28 days and once after a 7 day washout. MS/MS scanning of 664 urine samples for 18 parent Anc (PAnc) and 42 predicted Anc metabolites (AncM) yielded 371 products (i.e., MS/MS X retention time (RT)). Flavonoid-based AncM, which were likely underestimated, were almost 20 times more abundant than PAnc. Together, PAnc and AncM accounted for about 1% of the daily Anc dose. Aglycone forms were >94% of the total. Cluster analysis of the 371 Anc identified about 55 major Anc that contributed about 80% to the total Anc. The abundance of flavonoidbased Anc-derived products in the gastrointestinal tract could contribute to the health benefits of Anc-rich berries.
分类号: R15`S
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