Residues of Salbutamol and Identification of Its Metabolites in Beef Cattle

文献类型： 外文期刊

第一作者： Zhang, Kai

作者： Zhang, Kai;Tang, Chaohua;Meng, Qingshi;Zhao, Qingyu;Liang, Xiaowei;Liu, Shengsheng;Zhang, Junmin;Du, Wei;Bo, Tao;Zhang, Zhixu

作者机构：

关键词： salbutamol;cattle;residues;metabolites;monitoring

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

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收录情况： SCI

摘要： Salbutamol, a selective beta(2)-agonist, endangers the safety of animal products because of its illegal use in food animals. In this work, residues of salbutamol and its metabolites were investigated to select appropriate targets and marker residues for monitoring the illegal use of salbutamol. Ten metabolites of salbutamol were identified from plasma, urine, liver, and kidney samples; of these, six were newly identified. There were significant differences (P < 0.01) between the parent (nonconjugated) and total (conjugated + nonconjugated) salbutamol concentrations in plasma, urine, liver, and kidney tissues: Salbutamol residues in urine were relatively higher than those in plasma and other internal tissues during the dosing period and were rapidly eliminated from plasma, heart, spleen, and kidney tissues during the withdrawal time. Total salbutamol was identified as more preferable than parent salbutamol as a marker residue, and urine and eye tissues were found to be more suitable as targets for preslaughter and postslaughter monitoring of the illegal use of salbutamol in beef cattle.

分类号： R15`S

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