Structural characterization and bioavailability of ternary nanoparticles consisting of amylose, alpha-linoleic acid and beta-lactoglobulin complexed with naringin

文献类型： 外文期刊

第一作者： Feng, Tao

作者： Feng, Tao;Wang, Ke;Liu, Fangfang;Ye, Ran;Zhu, Xiao;Zhuang, Haining;Xue, Zhimin

作者机构：

关键词： Ternary nanoparticles;Naringin;Inclusion complex;Structural characterization;Bioavailability

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Naringin is a bioflavonoid that is rich in citrus plants and possesses enormous health benefits. However, the use of naringin as a nutraceutical is significantly limited by its low bioavailability. In this study, a novel water-soluble ternary nanoparticle material consisting of amylose, alpha-linoleic acid and beta-lactoglobulin was developed to encapsulate naringin to improve its bioavailability. The physicochemical characteristics of the ternary nanoparticle-naringin inclusion complex were analysed by ultraviolet-visible spectroscopy (UV), Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), high-resolution transmission electron microscopy (TEM), X-ray diffractometry (XRD) and particle size distribution. The results confirmed the formation of the ternary nanoparticle-naringin inclusion complex. The encapsulation efficiency (EE) and loading content (LC) of the ternary nanoparticle-naringin inclusion complex were 78.73 +/- 4.17% and 14.51 +/- 3.43%, respectively. In addition, the results of the ternary nanoparticle-naringin inclusion complex in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) demonstrated that naringin can be gradually released from the complex. In conclusion, ternary nanoparticles are considered promising carriers to effectively improve the bioavailability of naringin. (C) 2017 Elsevier B.V. All rights reserved.

分类号： Q71

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