The Effect of Butin on the Vitiligo Mouse Model Induced by Hydroquinone

文献类型： 外文期刊

第一作者： Huo, Shi-Xia

作者： Huo, Shi-Xia;Liu, Xin-Min;Gao, Li;Peng, Xiao-Ming;Yan, Ming;Wang, Qiong;Wang, Qiong;Liu, Xin-Min;Ge, Chun-Hui

作者机构：

关键词： butin;vitiligo;mouse;hydroquinone

期刊名称：PHYTOTHERAPY RESEARCH （ 影响因子：5.878； 五年影响因子：5.286 ）

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收录情况： SCI

摘要： Vernonia anthelmintica (L.) Willd has been traditionally used in the treatment of vitiligo in Uyghur medicine. This study used butin, the main component of V.anthelmintica, to study the influence on hydroquinone-induced vitiligo in mice. The animals were randomly divided into six groups: control, model, 8-methoxypsoralen (8-MOP, 4.25mg/kg), and butin (0.425, 4.25, and 42.5mg/kg) groups. The number of melanin-containing hair follicles, basal layer melanocytes, melanin-containing epidermal cells, the expression of tyrosinase (TYR) and tyrosinase-related protein-1 (TRP-1), the malondialdehyde (MDA), and cholinesterase (CHE) activity in serum were measured. Our results indicated that compared with the model group, the melanin-containing hair follicles, the expression of TYR and TRP-1 increased, the activity of CHE decreased after treatment with 8-MOP and all doses of butin (p<0.05, p<0.01), the basal layer melanocytes and melanin-containing epidermal cells increased significantly after treatment with butin 4.25 and 42.5mg/kg (p<0.05, p<0.01), and the MDA activity decreased after using butin 4.25 and 42.5mg/kg and 8-MOP (p<0.05, p<0.01). Our results support the use of butin on vitiligo, and its possible mechanisms may be related to increase the TYR and TRP-1 protein expression and decrease the activity of MDA and CHE in hydroquinone-induced vitiligo model in mice. Copyright (c) 2017 John Wiley & Sons, Ltd.

分类号： R243

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