Chemical Composition and Acetylcholinesterase Inhibitory Activity of Essential Oils from Piper Species

文献类型： 外文期刊

第一作者： Xiang, Cai-Peng

作者： Xiang, Cai-Peng;Han, Jia-Xin;Chen, Lin;Li, Hai-Zhou;Yang, Chong-Ren;Xu, Min;Zhao, San-Jun;Li, Xing-Cong;Li, Yun-Hui;Zhang, Yi;Yang, Chong-Ren;Hao, Chao-Yun;Qu, Yan;Yang, Chong-Ren

作者机构：

关键词： essential oil;Piper;P. hispidimervium;asaricin;acetylcholinesterase inhibitory activity

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

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收录情况： SCI

摘要： The essential oils (EOs) derived from aromatic plants such as Piper species are considered to play a role in alleviating neuronal ailments that are associated with inhibition of acetylcholinesterase (AChE). The chemical compositions of 23 EOs prepared from 16 Piper spp. were analyzed by both gas chromatography with a flame ionization detector (GC-FID) and gas chromatography-mass spectrometry (GC-MS). A total of 76 compounds were identified in the EOs from the leaves and stems of 19 samples, while 30 compounds were detected in the EOs from the fruits of four samples. Sesquiterpenes and phenylpropanoids were found to be rich in these EOs, of which asaricin, caryophyllene, caryophyllene oxide, isospathulenol, (+)-spathulenol, and beta-bisabolene are the major constituents. The EOs from the leaves and stems of Piper austrosinense, P. puberulum, P. flaviflorum, P. betle, and P. hispidimervium showed strong AChE inhibitory activity with IC50 values in the range of 1.51 to 13.9 mg/mL. A thin-layer chromatography (TLC) bioautography assay was employed to identify active compound(s) in the most active EO from P. hispidimervium. The active compound was isolated and identified as asaricin, which gave an IC50 value of 0.44 +/- 0.02 mg/mL against AChE, comparable to galantamine with an IC50 0.15 +/- 0.01 mg/mL.

分类号： R15`S

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