Secondary Haemophilus parasuis infection enhances highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) infection-mediated inflammatory responses

文献类型： 外文期刊

第一作者： Li, Jiangnan

作者： Li, Jiangnan;Wang, Shengnan;Li, Changyao;Wang, Chunlai;Liu, Yonggang;Wang, Gang;He, Xijun;Hu, Liang;Liu, Yuanyuan;Cui, Mengmeng;Bi, Caihong;Shao, Zengyu;Cai, Xuehui;Huang, Li;Weng, Changjiang;Wang, Xiaojie;Xiong, Tao

作者机构：

关键词： HP-PRRSV;Haemophilus parasuis;Secondary bacterial infection;Inflammatory response;IL-1 beta

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.293； 五年影响因子：3.599 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) infection often predisposes pigs to secondary bacterial infection, which induces robust inflammatory responses. However, whether the secondary bacterial infection synergizes HP-PRRSV infection and enhances inflammatory responses is not fully understood. Here, we characterized HP-PRRSV infection-mediated secondary bacterial infection and robust inflammatory responses. HP-PRRSV infection induced higher levels of cytokines (IL-1 beta, IL-18, IL-6 and TNF-alpha) in the sera in piglets and bacterial loads of 11 bacterial species in the lung were increased after HP-PRRSV infection, including Mycoplasma hyorhinis, Haemophilus parasuis and Escherichia coli. Concurrent infection with HP-PRRSV and H. parasuis model showed that inflammatory cytokines expression and secretion in porcine alveolar macrophages (PAMs) were increased in comparison with PAMs infected with HP-PRRSV or H. parasuis alone. Additionally, we found that H. parasuis RNA plays an important role in the robust inflammatory response enhancement in HP-PRRSV-infected PAMs. Taken together, our findings suggest that bacterial RNA transfection enhanced HP-PRRSV-mediated inflammatory responses in HP-PRRSV and H. parasuis (HPS) concurrent infection, which provides an important clue for comprehensive understanding of HP-PRRSV and bacterial coinfectionmediated pathology.

分类号： S8

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