Structural proteins of Helicoverpa armigera densovirus 2 enhance transcription of viral genes through transactivation

文献类型： 外文期刊

第一作者： Xu, Pengjun

作者： Xu, Pengjun;Yuan, He;Yang, Xianming;Wu, Kongming;Xu, Pengjun;Graham, Robert I.;Liu, Kaiyu

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期刊名称：ARCHIVES OF VIROLOGY （ 影响因子：2.574； 五年影响因子：2.466 ）

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收录情况： SCI

摘要： Herein, we report the identification of putative promoters for the non-structural proteins (NS) and capsid structural proteins (VP) of Helicoverpa armigera densovirus (HaDV2) as well as a potential mechanism for how these promoters might be regulated. For the first time, we report that VP is able to transactivate the VP promoter and, to a lesser degree, the NS promoter in densoviruses. In addition to this, another promoter-like sequence designated P2, when co-transfected with the VP gene, enhanced luciferase activity by approximately 35 times compared to a control. This suggests that there are two promoters for VP in HaDV2 and that the VP of parvoviruses might play a more important role in viral transcription than previously appreciated.

分类号： R37

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