Chimeric virus-like particles elicit protective immunity against serotype O foot-and-mouth disease virus in guinea pigs

文献类型: 外文期刊

第一作者: Liu, Xinsheng

作者: Liu, Xinsheng;Fang, Yuzhen;Zhou, Peng;Lu, Yanzhen;Zhang, Qiaoling;Xiao, Shuai;Dong, Zhaoliang;Pan, Li;Lv, Jianliang;Zhang, Zhongwang;Zhang, Yongguang;Wang, Yonglu;Liu, Xinsheng;Fang, Yuzhen;Zhou, Peng;Lu, Yanzhen;Zhang, Qiaoling;Xiao, Shuai;Dong, Zhaoliang;Pan, Li;Lv, Jianliang;Zhang, Zhongwang;Zhang, Yongguang;Wang, Yonglu;Lu, Yanzhen;Xiao, Shuai

作者机构:

关键词: FMDV;Virus-like particles;Baculovirus expression system;Guinea pig challenge

期刊名称:APPLIED MICROBIOLOGY AND BIOTECHNOLOGY ( 影响因子:4.813; 五年影响因子:4.697 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: Foot-and-mouth disease (FMD) is an acute and highly contagious disease caused by foot-and-mouth disease virus (FMDV) that can affect cloven-hoofed animal species, leading to severe economic losses worldwide. Therefore, the development of a safe and effective new vaccine to prevent and control FMD is both urgent and necessary. In this study, we developed a chimeric virus-like particle (VLP) vaccine candidate for serotype O FMDV and evaluated its protective immunity in guinea pigs. Chimeric VLPs were formed by the antigenic structural protein VP1 from serotype O and segments of the viral capsid proteins (VP2, VP3, and VP4) from serotype A. The chimeric VLPs elicited significant humoral and cellular immune responses with a higher level of anti-FMDV antibodies and cytokines than the control group. Furthermore, four of the five guinea pigs vaccinated with the chimeric VLPs were completely protected against challenge with 100 50% guinea pig infectious doses (GPID(50)) of the virulent FMDV strain O/MAY98. These data suggest that chimeric VLPs are potential candidates for the development of new vaccines against FMDV.

分类号: Q939.9`Q81

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