Passive immunotherapy for Middle East Respiratory Syndrome coronavirus infection with equine immunoglobulin or immunoglobulin fragments in a mouse model

文献类型： 外文期刊

第一作者： Zhao, Yongkun

作者： Zhao, Yongkun;Wang, Chong;Qiu, Boning;Wang, Hualei;Jin, Hongli;Gai, Weiwei;Zheng, Xuexing;Wang, Tiecheng;Sun, Weiyang;Yan, Feihu;Gao, Yuwei;Yang, Songtao;Xia, Xianzhu;Wang, Chong;Qiu, Boning;Gai, Weiwei;Penman, Stanley;Li, Chufang;Wang, Qian;Chen, Ling;Zhong, Nanshan;Zhao, Jincun;Zhao, Yongkun;Wang, Hualei;Wang, Tiecheng;Sun, Weiyang;Gao, Yuwei;Yang, Songtao;Xia, Xianzhu;Yan, Jinghua

作者机构：

关键词： Middle East Respiratory Syndrome coronavirus;Equine immune serum;Immunoglobulin;F(ab ')(2) fragment;Animal model

期刊名称：ANTIVIRAL RESEARCH （ 影响因子：5.97； 五年影响因子：5.801 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Middle East Respiratory Syndrome (MERS) is a highly lethal pulmonary infection caused by a coronavirus (Coy), MERS-CoV. With the continuing spread of MERS-CoV, prophylactic and therapeutic treatments are urgently needed. In this study, we prepared purified equine F(ab')(2) from horses immunized with MERS-CoV virus-like particles (VLPs) expressing MERS-CoV S, M and E proteins. Both IgG and F(ab')(2) efficiently neutralized MERS-CoV replication in tissue culture. Passive transfer of equine immune antibodies significantly reduced virus titers and accelerated virus clearance from the lungs of MERS-CoV infected mice. Our data show that horses immunized with MERS-CoV VLPs can serve as a primary source of protective F(ab')(2) for potential use in the prophylactic or therapeutic treatment of exposed or infected patients. (C) 2016 Published by Elsevier B.V.

分类号： R37

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