Research advances in interactions related to Toxoplasma gondii microneme proteins

文献类型: 外文期刊

第一作者: Liu, Qing

作者: Liu, Qing;Li, Fa-Cai;Zhou, Chun-Xue;Zhu, Xing-Quan;Liu, Qing;Zhu, Xing-Quan;Zhou, Chun-Xue;Zhou, Chun-Xue

作者机构:

关键词: Toxoplasma gondii;Microneme proteins;Protein-protein interactions;Protein-carbohydrate interactions;Host cells

期刊名称:EXPERIMENTAL PARASITOLOGY ( 影响因子:2.011; 五年影响因子:2.132 )

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收录情况: SCI

摘要: Toxoplasma gondii microneme proteins (TgMICs), secreted by micronemes upon contact with host cells, are reported to play important roles in multiple stages of the T. gondii life cycle, including parasite motility, invasion, intracellular survival, and egress from host cells. Meanwhile, during these processes, TgMICs participate in many protein-protein and protein-carbohydrate interactions, such as undergoing proteolytic maturation, binding to aldolase, engaging the host cell receptors and forming the moving junction (MJ), relying on different types of ectodomains, transmembrane (TM) domains and cytoplasmic domains (CDs). In this review, we summarize the research advances in protein-protein and protein carbohydrate interactions related to TgMICs, and their intimate associations with corresponding biological processes during T gondii infection, which will contribute to an improved understanding of the molecular pathogenesis of T gondii infection, and provide a basis for developing effective control strategies against T gondii. (C) 2017 Elsevier Inc. All rights reserved.

分类号: Q958.9

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