Pharmacokinetics of sulfamethoxazole and trimethoprim in Pacific white shrimp, Litopenaeus vannamei, after oral administration of single-dose and multiple-dose

文献类型： 外文期刊

第一作者： Ma, Rongrong

作者： Ma, Rongrong;Wang, Yuan;Zou, Xiong;Sun, Beibei;Fang, Wenhong;Fu, Guihong;Ma, Rongrong;Hu, Kun;Yang, Xianle

作者机构：

关键词： Sulfamethoxazole and trimethoprim;Pharmacokinetics;Single-dose and multiple-dose;Pacific white shrimp;Tissue distribution

期刊名称：ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY （ 影响因子：4.86； 五年影响因子：4.462 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： The tissue distribution and depletion of sulfamethoxazole (SMZ) and trimethoprim (TMP) were studied in Pacific white shrimp, Litopenaeus vannamei, after single-dose and multiple-dose oral administration of SMZ-TMP (5:1) via medicated feed. In single-dose oral administration, shrimps were fed once at a dose of 100 mg/kg (drug weight/body weight). In multiple-dose oral administration, shrimps were fed three times a day for three consecutive days at a dose of 100 mg/kg. The results showed the kinetic characteristic of SMZ was different from TMP in Pacific white shrimp. In the single-dose administration, the SMZ was widely distributed in the tissues, while TMP was highly concentrated in the hepatopancreas. The t(1/2z) values of SMZ were larger and persist longer than TMP in Pacific white shrimp. In the multiple-dose administration, SMZ accumulated well in the tissues, and reached steady state level after successive administrations, while TMP did not. TMP concentration even appeared the downward trend with the increase of drug times. Compared with the single dose, the tvzz values of SMZ in hepatopancreas (8.22-11.33 h) and muscle (6.53-10.92 h) of Pacific white shrimps rose, but the haemolymph dropped (13.76-11.03) in the multiple-dose oral administration. Meanwhile, the corresponding values of TMP also rose in hepatopancreas (4.53-9.65 h) and muscle (2.12-2.71 h), and declined in haemolymph (7.38-5.25 h) following single-dose and multiple-dose oral administration in Pacific white shrimps. In addition, it is worth mentioning that the ratios of SMZ and TMP were unusually larger than the general aim ratio.

分类号： R9

  • 相关文献

[1]Pharmacokinetics, Tissue Distribution, and Elimination of Flumequine in Japanese Seabass (Lateolabrax japonicus) following Intraperitoneal Injection and Oral Gavage. Hu, Lin-lin,Fang, Wen-hong,Zhou, Kai,Xia, Lian-jun,Zhou, Shuai,Lou, Bao,Shi, Hui-lai. 2011

[2]Validated hydrophilic interaction LC-MS/MS method for simultaneous quantification of dacarbazine and 5-amino-4-imidazole-carboxamide in human plasma. Yang, Yuhui,Zhang, Weihua,Liu, Yanhong.

[3]Effect of cinnamaldehyde on melanosis and spoilage of Pacific white shrimp (Litopenaeus vannamei) during storage. Mu, Honglei,Chen, Hangjun,Fang, Xiangjun,Mao, Jinlin,Gao, Haiyan. 2012

[4]Purification and characteristics of serine protease from the head of pacific white shrimp. Wu, Yanyan,Li, Laihao,Yang, Xianqing,Diao, Shiqiang,Wang, Ping. 2012

[5]Distribution and Metabolism of Bt-Cry1Ac Toxin in Tissues and Organs of the Cotton Bollworm, Helicoverpa armigera. Li, Yunhe,Xiao, Yutao,Ali, Abid,Dhiloo, Khalid Hussain,Chen, Wenbo,Wu, Kongming,Ali, Abid,Dhiloo, Khalid Hussain. 2016

[6]Tissue distribution and expression of signaling lymphocyte activation molecule receptor to peste des petits ruminant virus in goats detected by real-time PCR. Meng, Xuelian,Dou, Yongxi,Zhai, Junjun,Zhang, Hairui,Yan, Fengchao,Shi, Xiaoni,Luo, Xuelong,Li, Hui,Cai, Xuepeng. 2011

[7]Occurrence and dietary exposure assessment of PFOS and PFOA in cultured Trachinotus ovatus in China. Meng, Di,Qian, Yongzhong,Meng, Di,Han, Gang,Guo, Mengmeng. 2017

[8]Expression and functional characterization of a gene associated with retinoid-interferon-induced mortality 19 (GRIM-19) from orange-spotted grouper (Epinephelus coioides). Shi, Yan,Zhu, Xinping,Chen, Kunci,Zhao, Zhe,Zhang, Qiya. 2013

[9]Molecular characterization and expression of a novel big defensin (Sb-BDef1) from ark shell, Scapharca broughtonii. Li, Meng,Zhu, Ling,Zhou, Chun-ya,Sun, Shan,Fan, Yan-jun,Zhuang, Zhi-meng,Li, Meng,Zhou, Chun-ya. 2012

[10]A novel serine protease with clip domain from scallop Chlamys farreri. Zhu, Ling,Song, Linsheng,Zhao, Jiangmin,Li, Chenghua,Xu, Wei,Zhu, Ling,Mao, Yuze. 2008

[11]Ontogeny expression of ghrelin, neuropeptide Y and cholecystokinin in blunt snout bream, Megalobrama amblycephala. Ping, H. -C.,Feng, K.,Zhang, G. -R.,Wei, K. -J.,Wang, W. -M.,Zou, G. -W.. 2014

[12]IDENTIFICATION AND CHARACTERIZATION OF TWO SENSORY NEURON MEMBRANE PROTEINS FROM Cnaphalocrocis medinalis (LEPIDOPTERA: PYRALIDAE). Liu, Su,Zhang, Yan-Ru,Zhou, Wen-Wu,Liang, Qing-Mei,Yuan, Xin,Cheng, Jiaan,Zhu, Zeng-Rong,Gong, Zhong-Jun,Gong, Zhong-Jun. 2013

[13]A defensin from clam Venerupis philippinarum: Molecular characterization, localization, antibacterial activity, and mechanism of action. Zhang, Linbao,Yang, Dinglong,Wang, Qing,Wu, Huifeng,Pei, Dong,Cong, Ming,Li, Fei,Ji, Chenglong,Zhao, Jianmin,Zhang, Linbao,Yang, Dinglong,Wang, Qing,Wu, Huifeng,Pei, Dong,Cong, Ming,Li, Fei,Ji, Chenglong,Zhao, Jianmin,Zhang, Linbao,Yang, Dinglong,Yuan, Zeyi.

[14]Functional analysis and induction of four novel goose (Anser cygnoides) avian beta-defensins in response to salmonella enteritidis infection. Ma, Deying,Zhou, Caiyuan,Zhang, Mingyue,Zhou, Caiyuan,Zhang, Mingyue,Han, Zongxi,Shao, Yuhao,Liu, Shengwang.

[15]Isolation and characterization of two novel C-type lectins from the oriental river prawn, Macrobrachium nipponense. Xiu, Yunji,Hou, Libo,Wang, Yinghui,Gu, Wei,Meng, Qingguo,Wang, Wen,Xiu, Yunji,Hou, Libo,Wang, Yinghui,Gu, Wei,Meng, Qingguo,Wang, Wen,Xiu, Yunji,Liu, Xiaoqian.

[16]Protocols for Investigating the Host-tissue Distribution, Transmission-mode, and Effect on the Host Fitness of a Densovirus in the Cotton Bollworm. Yuan, He,Wu, Kongming,Xu, Pengjun,Graham, Robert I.. 2017

[17]Identification and tissue distribution of carboxylesterase (CXE) genes in Athetis lepigone (Lepidoptera: Noctuidae) by RNA-seq. Zhang, Ya-Nan,Zhu, Xiu-Yun,Qian, Jia-Li,Li, Zhao-Qun,Dong, Zhi-Ping,Xu, Lu,He, Peng. 2017

[18]Odorant Binding Characteristics of Three Recombinant Odorant Binding Proteins in Microplitis mediator (Hymenoptera: Braconidae). Wang, Shanning,Ren, Liyan,Ali, Abid,Zhang, Yongjun,Guo, Yuyuan,Li, Keming,Zhang, Kang,Zhou, Jingjiang.

[19]Characterization of a novel member of genus Iflavirus in Helicoverpa armigera. Xu, Pengjun,Yang, Xianming,Wu, Kongming,Xu, Pengjun,Graham, Robert I.,Wilson, Kenneth.

[20]Characterization and biological function analysis of the trim3a gene from zebrafish (Danio rerio). Zhang, Xinshang,Zhao, Heng,Chen, Yeyu,Meng, Kun,Yang, Peilong,Wang, Yaru,Wang, Guozeng,Yao, Bin,Liu, Chao. 2012

作者其他论文 更多>>

微信小程序