Impacts of different expressions of PA-X protein on 2009 pandemic H1N1 virus replication, pathogenicity and host immune responses

文献类型： 外文期刊

第一作者： Leea, Jinhwa

作者： Leea, Jinhwa;Yua, Hai;Li, Yonghai;Ma, Jingjiao;Lang, Yuekun;Duff, Michael;Henningson, Jamie;Liu, Qinfang;Li, Yuhao;Nagy, Abdou;Bawa, Bhupinder;Richt, Juergen A.;Ma, Wenjun;Yua, Hai;Liu, Qinfang;Li, Zejun;Tong, Guangzhi;Nagy, Abdou

作者机构：

关键词： Influenza A virus;PA-X;Virus replication;Host immune response

期刊名称：VIROLOGY （ 影响因子：3.616； 五年影响因子：3.967 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Although several studies have investigated the functions of influenza PA-X, the impact of different expressions of PA-X protein including full-length, truncated or PA-X deficient forms on virus replication, pathogenicity and host response remains unclear. Herein, we generated two mutated viruses expressing a full-length or deficient PA-X protein based on the A/California/04/2009 (H1N1) virus that expresses a truncated PA-X to understand three different expressions of PA-X protein on virus replication, pathogenicity and host immune responses. The results showed that expression of either full-length or truncated PA-X protein enhanced viral replication and pathogenicity as well as reduced host innate immune response in mice by host shutoff activity when compared to the virus expressing the deficient PA-X form. Furthermore, the full-length PA-X expression exhibited a greater effect on virus pathogenicity than the truncated PA-X form. Our results provide novel insights of PA-X on viral replication, pathogenicity and host immune responses.

分类号： R37

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