Purification, in vitro antioxidant and in vivo anti-aging activities of exopolysaccharides by Agrocybe cylindracea

文献类型: 外文期刊

第一作者: Zhao, Huajie

作者: Zhao, Huajie;Zhang, Jianjun;Wang, Xiuxiu;Hao, Long;Jia, Le;Li, Juan

作者机构:

关键词: Agrocybe cylindraceas;Anti-aging activities;Antioxidant activities;Exopolysaccharides

期刊名称:INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES ( 影响因子:6.953; 五年影响因子:6.737 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: The in vitro antioxidant and in vivo anti-aging activities in D-galactose-induced aging mice of exopolysaccharides (EPS) and its fractions (EPS-1, EPS-2 and EPS-3) by Agrocybe cylindraceas were investigated presently. The scavenging effects of EPS-2 on hydroxyl (HO center dot) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals were 97.1 +/- 4.25% and 90.23 +/- 13.25%, while the reducing power reached 1.18 +/- 0.08 at 120 mg/L, which were higher than EPS, EPS-1 and EPS-3 at 1000 mg/L. The EPS showed potential anti-aging activities via reducing the contents of malonaldehyde (MDA) and total cholesterol (TC), as well as increasing the activities of superoxide dismutase (SOD) activities, glutathione peroxidase (GSH-Px) activities, and total antioxidant capacity (T-AOC). Additionally, the monosaccharide analysis showed EPS contained rhamnose and glucose with the molar ratio of 2.8:1. These results demonstrated that EPS could be used as functional foods and natural drugs on preventing and mitigating the aging process. (C) 2017 Elsevier B.V. All rights reserved.

分类号: Q71

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