Marek's disease virus type 1 encoded analog of miR-155 promotes proliferation of chicken embryo fibroblast and DF-1 cells by targeting hnRNPAB

文献类型： 外文期刊

第一作者： Dang, Lu

作者： Dang, Lu;Zhou, En-Min;Zhang, Gai-Ping;Dang, Lu;Teng, Man;Li, Hui-Zhen;Ma, Sheng-Ming;Lu, Qing-Xia;Hao, Hui-Fang;Zhao, Dong;Luo, Jun;Li, Hui-Zhen;Zhang, Gai-Ping;Ma, Sheng-Ming;Luo, Jun;Zhang, Gai-Ping

作者机构：

关键词： Herpesvirus;MDV;miR-M4-5p;miR-155;hnRNPAB;CEF;DF-1;Proliferation

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.293； 五年影响因子：3.599 ）

ISSN：

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收录情况： SCI

摘要： Marek's disease virus type 1 (MDV-1) is a representative oncogenic Alpha herpesvirus that causes an immunosuppressive and neoplastic lymphoproliferative avian disease, namely Marek's disease (MD). The rapid onset T-cell lymphoma in chickens induced by MDV-1 has been historically regarded as an ideal natural model for herpesvirus-related cancer research. As a viral analog of cellular miR-155, the MDV-1-encoded miR-M4-5p has been shown to be crucial for the virally-induced MD tumorigenesis. Our previous studies demonstrated that miR-M4-5p induces an over-expression of oncogene c-Myc by targeting LTBP1 and suppressing the TGF-D signaling pathway during MDV-1 infection. We have now further identified the chicken heterogeneous nuclear ribonucleoprotein AB (hnRNPAB) as a new cellular biological target for miR-M4-5p. Suppression of hnRNPAB expression mediated by miR-M4-5p promotes the proliferation, but not the apoptosis, of both primary chicken embryo fibroblasts (CEFs) and transformed chicken fibroblast DF-1 cell line. HnRNPAB is a member of the hnRNP family of proteins that play important roles in normal biological processes as well as cancer development. Our data suggests that the recognition and down-regulation of hnRNPAB by miR-M4-5p may be one of the important strategies for MDV-1 to trigger the development of MD lymphomas.

分类号： S8

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