Protective effects of Lactobacillus plantarum C88 on chronic ethanol-induced liver injury in mice
文献类型: 外文期刊
第一作者: Zhao, Lei
作者: Zhao, Lei;Jiang, Yu;Ni, Yuxin;Zhang, Tianzhu;Duan, Cuicui;Huang, Cheng;Zhao, Yujuan;Gao, Lei;Li, Shengyu
作者机构:
关键词: Lactobacillus plantarum;Hepatoprotective;Anti-oxidation;Anti-inflammation;Intestinal barrier
期刊名称:JOURNAL OF FUNCTIONAL FOODS ( 影响因子:4.451; 五年影响因子:4.907 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: The protective effects of L plantarum C88 against chronic alcohol-induced liver injury in mice were investigated. The pretreatment with L plantarum C88 significantly decreased the levels of alanine transaminase and aspartate aminotransferase in chronic alcohol-challenged mice. L plantarum C88 was also found to suppress the content of malondialdehyde (MDA) and enhance the activity of superoxide dismutase (SOD) in the liver, which are well-correlated with the downregulation of hepatic cytochrome P450 2E1 and upregulation of nuclear factor erythroid 2-related factor 2 (Nrf2). Moreover, L plantarum C88 significantly abrogated the increased serum levels of TNF-alpha, IL-6, and IFN-gamma induced by ethanol. L plantarum C88 ameliorated gut leakiness by upregulating the expressions of tight junction proteins and suppressed the endotoxin-mediated inflammation by decreasing P38 phosphorylation and down-regulating NF-kappa B. These results demonstrate that L plantarum C88 efficiently protects against alcoholic chronic liver injury. (C) 2017 Elsevier Ltd. All rights reserved.
分类号: TS2
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