Protective effects of Lactobacillus plantarum C88 on chronic ethanol-induced liver injury in mice

文献类型: 外文期刊

第一作者: Zhao, Lei

作者: Zhao, Lei;Jiang, Yu;Ni, Yuxin;Zhang, Tianzhu;Duan, Cuicui;Huang, Cheng;Zhao, Yujuan;Gao, Lei;Li, Shengyu

作者机构:

关键词: Lactobacillus plantarum;Hepatoprotective;Anti-oxidation;Anti-inflammation;Intestinal barrier

期刊名称:JOURNAL OF FUNCTIONAL FOODS ( 影响因子:4.451; 五年影响因子:4.907 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: The protective effects of L plantarum C88 against chronic alcohol-induced liver injury in mice were investigated. The pretreatment with L plantarum C88 significantly decreased the levels of alanine transaminase and aspartate aminotransferase in chronic alcohol-challenged mice. L plantarum C88 was also found to suppress the content of malondialdehyde (MDA) and enhance the activity of superoxide dismutase (SOD) in the liver, which are well-correlated with the downregulation of hepatic cytochrome P450 2E1 and upregulation of nuclear factor erythroid 2-related factor 2 (Nrf2). Moreover, L plantarum C88 significantly abrogated the increased serum levels of TNF-alpha, IL-6, and IFN-gamma induced by ethanol. L plantarum C88 ameliorated gut leakiness by upregulating the expressions of tight junction proteins and suppressed the endotoxin-mediated inflammation by decreasing P38 phosphorylation and down-regulating NF-kappa B. These results demonstrate that L plantarum C88 efficiently protects against alcoholic chronic liver injury. (C) 2017 Elsevier Ltd. All rights reserved.

分类号: TS2

  • 相关文献

[1]Lychee (Litchi chinensis Sonn.) Pulp Phenolic Extract Provides Protection against Alcoholic Liver Injury in Mice by Alleviating Intestinal Microbiota Dysbiosis, Intestinal Barrier Dysfunction, and Liver Inflammation. Xiao, Juan,Zhang, Ruifen,Liu, Lei,Huang, Fei,Deng, Yuanyuan,Ma, Yongxuan,Wei, Zhencheng,Tang, Xiaojun,Zhang, Mingwei,Zhou, Qiuyun.

[2]Effect of a probiotic mixture on intestinal microflora, morphology, and barrier integrity of broilers subjected to heat stress. Song, J.,Xiao, K.,Ke, Y. L.,Jiao, L. F.,Hu, C. H.,Zou, X. T.,Diao, Q. Y.,Shi, B.. 2014

[3]Cello-oligosaccharide ameliorates heat stress-induced impairment of intestinal microflora, morphology and barrier integrity in broilers. Song, J.,Jiao, L. F.,Xiao, K.,Luan, Z. S.,Hu, C. H.,Zhan, X. A.,Luan, Z. S.,Shi, B..

[4]Effects of cello-oligosaccharide on intestinal microbiota and epithelial barrier function of weanling pigs. Jiao, L. F.,Ke, Y. L.,Xiao, K.,Song, Z. H.,Hu, C. H.,Shi, B..

[5]Effects of diosmectite-Lactobacillus acidophilus on growth performance, intestine microbiota, mucosal architecture of weaned pigs. Cao, Shuting,Jiao, Lefei,Lin, Fanghui,Xiao, Kan,Hu, Caihong,Wang, Li.

[6]Effect of Polysaccharides from Acanthopanax senticosus on Intestinal Mucosal Barrier of Escherichia coli Lipopolysaccharide Challenged Mice. Han, Jie,Xu, Yunhe,Yang, Di,Yu, Ning,Bai, Zishan,Bian, Lianquan,Xu, Yunhe,Yu, Ning.

[7]Antioxidative and Hepatoprotective Activities of Deinoxanthin-Rich Extract from Deinococcus radiodurans R1 against Carbon Tetrachloride-Induced Liver Injury in Mice. Cheng, Jianhui,Zheng, Zhiguo,Tian, Bing,Hua, Yuejin,Cheng, Jianhui,Zhang, Zuofa,Lv, Guoying,Zheng, Zhiguo. 2014

[8]Hepatoprotective effect of Coreopsis tinctoria flowers against carbon tetrachloride-induced liver damage in mice. Tsai, Jen-Chieh,Chiu, Chuan-Sung,Kao, Chun-Pin,Chen, Yun-Chieh,Lee, Meng-Shiou,Hsieh, Ming-Tsuen,Peng, Wen-Huang,Hao, Xiu-Ying. 2017

[9]Antihyperlipidaemic and hepatoprotective activities of acidic and enzymatic hydrolysis exopolysaccharides from Pleurotus eryngii SI-04. Gong, Zhiyuan,Zhang, Chen,Song, Xingling,Zhang, Jianjun,Jia, Le,Li, Juan,Wang, Jing,Wu, Shang,Hu, Chunlong. 2017

[10]Esters of new oleanane-type triterpenoid saponins from Schefflera kwangsiensis. Wang, Yan,Zhang, Lei-Lei,Zhang, Chun-Lei,Liu, Yan-Fei,Liang, Dong,Luo, Huan,Hao, Zhi-You,Chen, Ruo-Yun,Yu, De-Quan,Wang, Yan,Zhang, Lei-Lei,Zhang, Chun-Lei,Liu, Yan-Fei,Liang, Dong,Luo, Huan,Hao, Zhi-You,Chen, Ruo-Yun,Yu, De-Quan,Wang, Yan,Zhang, Lei-Lei.

[11]Characterization of Polysaccharides with Antioxidant and Hepatoprotective Activities from the Edible Mushroom Oudemansiella radicata. Liu, Qin,Liu, Qin,Wang, Hexiang,Zhu, Mengjuan,Geng, Xueran,Ng, Tzi Bun.

[12]The antihyperlipidemic activities of enzymatic and acidic intracellular polysaccharides by Termitomyces albuminosus. Zhao, Huajie,Liu, Yu,Zhao, Huajie,Li, Shangshang,Zhang, Jianjun,Liu, Min,Zhang, Chen,Xu, Nuo,Lin, Lin,Jia, Le,Che, Gen,Zhou, Meng.

[13]Two new lupane saponins from Schefflera kwangsiensis. Wang, Yan,Zhang, Chun-Lei,Liu, Yan-Fei,Chen, Ruo-Yun,Yu, De-Quan,Wang, Yan,Zhang, Chun-Lei,Liu, Yan-Fei,Chen, Ruo-Yun,Yu, De-Quan,Wang, Yan,Wang, Feng-Zhong.

[14]Inhibitory effect of Malvidin on TNF-alpha-induced inflammatory response in endothelial cells. Huang, Wu-Yang,Wang, Jian,Li, Chun-Yang,Wang, Jian,Liu, Ya-Mei,Zheng, Qi-Sheng. 2014

[15]Evaluation of Antibacterial and Anti-inflammatory Activities of Less Polar Ginsenosides Produced from Polar Ginsenosides by Heat-transformation. Wang, Lijun,Yang, Xiushi,Yu, Xiaona,Yao, Yang,Ren, Guixing,Wang, Lijun,Yang, Xiushi,Yu, Xiaona.

[16]Identification and characterization of Bacillus subtilis from grass carp (Ctenopharynodon idellus) for use as probiotic additives in aquatic feed. Guo, Xia,Chen, Dan-Dan,Peng, Kai-Song,Cui, Zheng-Wei,Zhang, Xu-Jie,Li, Shun,Zhang, Yong-An,Guo, Xia,Peng, Kai-Song,Cui, Zheng-Wei,Zhang, Xu-Jie.

[17]Porcine glucagon-like peptide-2 microspheres ameliorate inflammation in lipopolysaccharide-challenged weaning piglets. Wu, J.,Qi, K. K.,Xu, Z. W..

[18]Polyphenols from blueberries modulate inflammation cytokines in LPS-induced RAW264.7 macrophages. Cheng, Anwei,Tian, Yaoqi,Cheng, Anwei,Yan, Haiqing,Han, Caijing,Wang, Wenliang,Chen, Xiangyan,Tian, Yaoqi.

[19]Anti-inflammatory properties of GLPss58, a sulfated polysaccharide from Ganoderma lucidum. Zhang, Kai,Zhao, Xiangli,Dernedde, Jens,Fan, Hua,Liu, Yanfang,Tang, Qingjiu,Zhang, Jingsong. 2018

[20]Tylvalosin exhibits anti-inflammatory property and attenuates acute lung injury in different models possibly through suppression of NF-kappa B activation. Zhao, Zhanzhong,Tang, Xiangfang,Zhang, Minhong,Hou, Shaohua,Yuan, Weifeng,Zhang, Hongfu,Shi, Lijun,Jia, Hong,Liang, Lin,Zhao, Zhanzhong,Zhao, Xinghui,Fu, Ling,Chen, Wei,Zhang, Weijian,Lai, Zhi,Gao, Junfeng,Zhang, Keyu. 2014

作者其他论文 更多>>