Correlation between gyrA and CmeR Box Polymorphism and Fluoroquinolone Resistance in Campylobacter jejuni Isolates in China

文献类型： 外文期刊

第一作者： Zhang, Tengfei

作者： Zhang, Tengfei;Cheng, Yiluo;Luo, Qingping;Lu, Qin;Dong, Jun;Zhang, Rongrong;Wen, Guoyuan;Wang, Honglin;Luo, Ling;Wang, Hongcai;Shao, Huabin;Zhang, Tengfei;Luo, Qingping;Lu, Qin;Zhang, Rongrong;Wen, Guoyuan;Wang, Honglin;Luo, Ling;Wang, Hongcai;Shao, Huabin;Cheng, Yiluo;Dong, Jun;Liu, Guoping

作者机构：

关键词： Campylobacter jejuni;DNA gyrase;cmeABC;fluoroquinolone resistance

期刊名称：ANTIMICROBIAL AGENTS AND CHEMOTHERAPY （ 影响因子：5.191； 五年影响因子：5.346 ）

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收录情况： SCI

摘要： Sequence analysis of 79 ciprofloxacin-resistant Campylobacter jejuni isolates collected in China showed resistance-related sequence variations in gyrA and CmeR-Box. All the isolates contain an identical Thr-86-Ile substitution in GyrA. Several novel CmeR-Box variations, including point substitutions, deletion, and insertion, were identified. The point insertion or deletion led to dramatically reduced binding of CmeR to the cmeABC promoter, which significantly increases the expression of cmeABC and contributes to the high fluoroquinolone resistance.

分类号： R45

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