Effects of florfenicol on the antioxidant status, detoxification system and biomolecule damage in the swimming crab (Portunus trituberculatus)

文献类型： 外文期刊

第一作者： Ren, Xianyun

作者： Ren, Xianyun;Wang, Zhuqing;Gao, Baoquan;Liu, Ping;Li, Jian;Ren, Xianyun;Wang, Zhuqing;Gao, Baoquan;Liu, Ping;Li, Jian;Wang, Zhuqing

作者机构：

关键词： Florfenicol;Portunus trituberculatus;Antioxidant status;Detoxification system;Biomolecule;Damage

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.291； 五年影响因子：6.393 ）

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年卷期：

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收录情况： SCI

摘要： Florfenicol (FLR) is the most commonly used antibacterial agent in aquaculture because of its wide spectrum of activity and few side-effects. We characterized the toxicokinetics of FLR in the swimming crab (Portunus trituberculatus) after intravenous (W) dosing (20, 40 and 80 mg/kg). The results showed that FLR significantly suppressed the antioxidant system of the hepatopancreas. FLR induced transcriptional expression of phase I and phase II detoxification genes (CYP3 and GST, respectively) in a dose- and clearance time-dependent manner and altered the expression of their corresponding enzymes (erythromycin N-demethylase and glutathione Stransferase, respectively). Moreover, FLR induced the transcription of ATP-binding cassette (ABC) transporter subfamily B (ABCB) and subfamily G (ABCG), although ABCG transcription was not induced by FLR at 20 mg/kg. Additionally, higher FLR doses caused significant biomolecule damage during the first 48 h after delivery. This study will provide an improved understanding of the exact mechanism underlying toxicity in aquatic organisms.

分类号： X`R12`R99

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