Pathogenicity of modified bat influenza virus with different M genes and its reassortment potential with swine influenza A virus

文献类型: 外文期刊

第一作者: Yang, Jianmei

作者: Yang, Jianmei;Lee, Jinhwa;Ma, Jingjiao;Lang, Yuekun;Nietfeld, Jerome;Li, Yuhao;Duff, Michael;Li, Yonghai;Yang, Yuju;Liu, Haixia;Richt, Juergen A.;Ma, Wenjun;Yang, Jianmei;Li, Zejun;Zhou, Bin;Wentworth, David E.;Zhou, Bin;Wentworth, David E.

作者机构:

关键词: modified bat influenza virus;M gene;pathogenicity;reassortment

期刊名称:JOURNAL OF GENERAL VIROLOGY ( 影响因子:3.891; 五年影响因子:3.719 )

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收录情况: SCI

摘要: In our previous studies, the reassortant virus containing only the PR8 H1N1 matrix (M) gene in the background of the modified bat influenza Bat09 : mH1mN1 virus could be generated. However, whether M genes from other origins can be rescued in the background of the Bat09 : mH1mN1 virus and whether the resulting novel reassortant virus is virulent remain unknown. Herein, two reassortant viruses were generated in the background of the Bat09 : mH1mN1 virus containing either a North American or a Eurasian swine influenza virus M gene. These two reassortant viruses and the reassortant virus with PR8 M as well as the control Bat09 : mH1mN1 virus replicated efficiently in cultured cells, while the reassortant virus with PR8 M grew to a higher titre than the other three viruses in tested cells. Mouse studies showed that reassortant viruses with either North American or Eurasian swine influenza virus M gene did not enhance virulence, whereas the reassortant virus with PR8 M gene displayed higher pathogenicity when compared to the Bat09 : mH1mN1 virus. This is most likely due to the fact that the PR8 H1N1 virus is a mouse- adapted virus. Furthermore, reassortment potential between the Bat09 : mH1mN1 virus and an H3N2 swine influenza virus (A/swine/Texas/4199-2/1998) was investigated using co-infection of Madin-Darby canine kidney cells, but no reassortant viruses were detected. Taken together, our results indicate that the modified bat influenza virus is most likely incapable of reassortment with influenza A viruses with in vitro co-infection experiments, although reassortant viruses with different M genes can be generated by reverse genetics.

分类号: R37

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