Chicken TBK1 interacts with STING and is involved in IFN-beta signaling regulation

文献类型: 外文期刊

第一作者: Cheng, Yuqiang

作者: Cheng, Yuqiang;Ma, Jingjiao;Liu, Yunxia;Yan, Yaxian;Wang, Hengan;Sun, Jianhe;Ding, Chan;Gao, Quanxin

作者机构:

关键词: Chicken;TANK-Binding kinase 1;Stimulator of interferon genes;IFN-beta;Avian influenza viruses

期刊名称:DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY ( 影响因子:3.636; 五年影响因子:3.654 )

ISSN:

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收录情况: SCI

摘要: TANK-binding kinase 1 (TBK1) is an essential serine/threonine-protein kinase required for the Toll-like receptor (TLR)- and retinoic acid-inducible gene I (RIG-I) -mediated induction of type I IFN. Through endogenous Co-IP and LC-MS/MS, we identified chicken TBK1 (chTBK1) as a chSTING-interactive protein. Through exogenous Co-IP assay in transfected cells, we confirmed the interaction between chSTING and chTBK1. To better understand the biological role of chTBK1 in the chSTING-mediated IFN pathway, we cloned the chTBK1 and investigated its biological functions. Quantitative RT-PCR showed that chTBK1 mRNA was widely expressed in different tissues. The overexpression of chTBK1 in DF-1 cells induced the expression of IFN-beta and ISGs and inhibited AIV viral replication. We identified indispensable domains of chTBK1 on IFN-beta production via the generation of various chTBK1 mutant forms. Together, we identified the chTBK1 as a chSTING interactive protein and concluded that chTBK1 is involved in chSTING-triggered IFN-beta signaling in chicken cells. (C) 2017 Elsevier Ltd. All rights reserved.

分类号: R392

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