Antioxidant and anti-cancer activities of proanthocyanidins-rich extracts from three varieties of sorghum (Sorghum bicolor) bran

文献类型： 外文期刊

第一作者： Zhu, Yingying

作者： Zhu, Yingying;Shi, Zhenxing;Yao, Yang;Hao, Yuqiong;Ren, Guixing;Zhu, Yingying;Shi, Zhenxing

作者机构：

关键词： Sorghum proanthocyanidins;antioxidant activity;anticancer activity;HepG2 cancer cells

期刊名称：FOOD AND AGRICULTURAL IMMUNOLOGY （ 影响因子：3.101； 五年影响因子：2.573 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Hepatocellular carcinoma is the fifth frequently diagnosed cancer in humans. Proanthocyanidins was reported to be an excellent dietary botanical supplement for its antioxidant and anticancer effects. In this study, proanthocyanidins-rich extracts (PREs) were prepared from three varieties (Jinza No. 12, Jinza No. 15 and Jinza No. 18) of sorghum bran. Their proanthocyanidins profiles were characterized. Antioxidant assay showed that PRE samples from Jinza No. 12 and Jinza No. 15 had significant higher (p <.05) hydroxyl radical, 1-diphenyl-2-picrylhydrazyl radical and oxygen radical-scavenging capacities compared to PRE from Jinza No. 18. Stronger anti-proliferation and inhibition of cell migration (p <.05) in HepG2 cancer cells were also demonstrated among the PRE samples from Jinza No.12 and Jinza No. 15. Intracellular signaling array analysis demonstrated an up-regulated level of phosphorylated 5'AMP-activated protein kinase a and down-regulated levels of phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2) and p38.

分类号： R392

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