Fluorescence enhancement thermoresponsive polymer luminescent sensors based on BODIPY for intracellular temperature

文献类型： 外文期刊

第一作者： Gong, Deyan

作者： Gong, Deyan;Cao, Ting;Iqbal, Anam;Liu, Weisheng;Qin, Wenwu;Gong, Deyan;Cao, Ting;Iqbal, Anam;Liu, Weisheng;Qin, Wenwu;Han, Shi-Chong;Zhu, Xiangtao;Guo, Huichen;Han, Shi-Chong;Zhu, Xiangtao;Guo, Huichen

作者机构：

关键词： BODIPY;NIPAM;Thermometer;Living cells;Polymer

期刊名称：SENSORS AND ACTUATORS B-CHEMICAL （ 影响因子：7.46； 五年影响因子：6.743 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Graphical abstract poly(NIPAM-co-BODIPY-AA) exhibits fluorescence intensity (λem =605nm) increases in temperature from 35°C up to 47°C and the fluorescent sensing in living cells. Display Omitted Highlights ? The water soluble copolymer hydrogel poly(NIPAM-co-BODIPY-AA) as nanothermometer has been synthesized. ? poly(NIPAM-co-BODIPY-AA) shows properties including good temperature-responsive reversibility and biocompatibility. ? The fluorescence intensity increased linearly with increasing physiology temperature (37–42°C). Abstract Herein, A water soluble, visible excited and simple-structured copolymer hydrogel, poly(NIPAM-co-BODIPY-AA), consisting of N-isopropylacrylamide (NIPAM) and derivative of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) units as thermoresponsive and polarity sensitive fluorescent signalling parts, respectively, has been synthesized. The copolymer exhibits weak fluorescence at temperature low than 35°C in aqueous solution, whereas the red fluorescence intensity (λem =605nm) increases with a 10 folds rise in temperature up to 47°C with an increase of average lifetime from 0.68ns up to 2ns in the thermal transition processes. The fluorescence intensity increased linearly with increasing physiology temperature (37–42°C). The resultant nanothermometer could feature a high and spontaneous uptaking into the BHK cells. The prepared nanothermometer which is user friendly can provide tools for unveiling intrinsic relationship between the intracellular temperature and could be used in further applications for the fluorescent temperature sensing included parts of physiological temperature range in living cells. ]]>

分类号： TP212.2

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