Antioxidant and hepatoprotective effects of A-cerana honey against acute alcohol-induced liver damage in mice

文献类型： 外文期刊

第一作者： Zhao, Haoan

作者： Zhao, Haoan;Cheng, Ni;He, Liangliang;Peng, Guoxia;Cao, Wei;Xue, Xiaofeng;Wu, Liming;Cheng, Ni;Cao, Wei

作者机构：

关键词： Hepatoprotective effect;Antioxidant;Alcohol;A. cerana honey

期刊名称：FOOD RESEARCH INTERNATIONAL （ 影响因子：6.475； 五年影响因子：6.508 ）

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收录情况： SCI

摘要： A. corona honey, gathered from Apis cerana Fabricius (A. corona), has not been fully studied. Samples of honey originating from six geographical regions (mainly in the Qinling Mountains of China) were investigated to determine their antioxidant and hepatoprotective effects against acute alcohol-induced liver damage. The results showed that A. cerana honeys from the Qinling Mountains had high total phenolic contents (345.1-502.1 mg GA kg(-1)), ascorbic acid contents (153.8-368.4 mg kg(-1)), and strong antioxidant activities in DPPH radical scavenging activity assays (87.5-136.21050 mg mL(-1)), ferric reducing antioxidant powers (191.8-317.4 mg Trolox kg(-1)), and ferrous ion-chelating activities (27.5-35.5 mg Na(2)EDTA kg(-1)). Pretreatment with A. arum honey (Qinling Mountains) at 5, 10, or 20 g kg(-1) twice daily for 12 weeks significantly inhibited serum lipoprotein oxidation and increased serum radical absorbance capacity (ORAC) (P < 0.05). Moreover, A. cerana honey inhibited acute alcohol-induced increases in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum (P < 0.05), reduced the production of hepatic malondialdehyde (MDA) (P < 0.05), and promoted superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) activities (P < 0.05). More importantly, it also remarkably inhibited the level of TGF-beta 1 in the serum and liver (P < 0.05). The results of this study indicate that administration of A. cerana honey prevents acute alcohol induced liver damage likely because of its antioxidant properties and ability to prevent oxidative stress.

分类号： TS2

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