Contribution of VMA5 to vacuolar function, stress response, ion homeostasis and autophagy in Candida albicans

文献类型： 外文期刊

第一作者： Jia, Chang

作者： Jia, Chang;Yu, Qilin;Xiao, Chenpeng;Dong, Yijie;Zhang, Meng;Zhang, Dan;Li, Mingchun;Dong, Yijie;Zhao, Qiang;Zhang, Biao

作者机构：

关键词： autophagy;calcium;Candida albicans;filamentous;oxidative stress;virulence;Vma5

期刊名称：FUTURE MICROBIOLOGY （ 影响因子：3.165； 五年影响因子：3.837 ）

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收录情况： SCI

摘要： Aim: V-ATPase is a conservative multi-subunit enzyme in eukaryotes and modulates several cellular responses. This study aimed to illustrate the roles of Vma5 in vacuolar function, oxidative stress response, calcium homeostasis, autophagy and virulence. Materials & methods: The vma5 Delta/Delta mutant was obtained using PCR-mediated homologous recombination. The functions of Vma5 were investigated by a series of biochemical and systemic infection methods. Results: Disruption of VMA5 led to growth inhibition, vacuolar dysfunction, disturbance of calcium homeostasis and inhibition of calcium-related oxidative stress response. Furthermore, its deletion caused defects in autophagy completion and hyphal development, and resulted in attenuated Candida albicans virulence. Conclusion: Our findings provide new insights into V-ATPase functions in C. albicans, and reveal a potential candidate for development of antifungal drugs.

分类号： Q93

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