Function of glutaredoxin 3 (Grx3) in oxidative stress response caused by iron homeostasis disorder in Candida albicans

文献类型： 外文期刊

第一作者： Zhang, Dan

作者： Zhang, Dan;Dong, Yijie;Yu, Qilin;Kai, Zhang;Zhang, Meng;Jia, Chang;Xiao, Chenpeng;Zhang, Bing;Li, Mingchun;Dong, Yijie;Zhang, Biao

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关键词： Candida albicans;Grx3;iron homeostasis;oxidative stress response

期刊名称：FUTURE MICROBIOLOGY （ 影响因子：3.165； 五年影响因子：3.837 ）

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收录情况： SCI

摘要： Aim: Glutaredoxin is a conserved oxidoreductase in eukaryotes and prokaryotes. This study aimed to determine the role of Grx3 in cell survival, iron homeostasis and the oxidative stress response in Candida albicans. Materials & methods: A grx3 Delta/Delta mutant was obtained using PCR-mediated homologs recombination. The function of Grx3 was investigated by a series of biochemical methods. Results: Deletion of GRX3 impaired growth and cell cycle, disturbance of iron homeostasis and activated the oxidative stress response. Furthermore, disruption of GRX3 caused oxidative damage and growth defects of C albicans. Conclusion: Our findings provide new insights into the role of GRX3 in C albicans.

分类号： Q93

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