Interferon-omega: Current status in clinical applications

文献类型： 外文期刊

第一作者： Li, Shi-fang

作者： Li, Shi-fang;Zhao, Fu-rong;Shao, Jun-jun;Xie, Yin-li;Chang, Hui-yun;Zhang, Yong-guang

作者机构：

关键词： Application;Biological activity;Interferon omega;Type I IFN

期刊名称：INTERNATIONAL IMMUNOPHARMACOLOGY （ 影响因子：4.932； 五年影响因子：4.624 ）

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收录情况： SCI

摘要： Abstract Since 1985, interferon (IFN)-ω, a type I IFN, has been identified in many animals, but not canines and mice. It has been demonstrated to have antiviral, anti-proliferation, and antitumor activities that are similar to those of IFN-α. To date, IFN-ω has been explored as a treatment option for some diseases or viral infections in humans and other animals. Studies have revealed that human IFN-ω displays antitumor activities in some models of human cancer cells and that it can be used to diagnose some diseases. While recombinant feline IFN-ω has been licensed in several countries for treating canine parvovirus, feline leukemia virus, and feline immunodeficiency virus infections, it also exhibits a certain efficacy when used to treat other viral infections or diseases. This review examines the known biological activity of IFN-ω and its clinical applications. We expect that the information provided in this review will stimulate further studies of IFN-ω as a therapeutic agent. Highlights ? Few systemically review about interferon omega is online. ? We provide a broad knowledge of the characteristics and biological functions of IFN-ω. ? We examine the known information of IFN-ω which used as potential application in treating some diseases or virus.

分类号： R96

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