EFFECT OF A LYTIC BACTERIOPHAGE ON RABBITS EXPERIMENTALLY INFECTED WITH PATHOGENIC ESCHERICHIA COLI

文献类型： 外文期刊

第一作者： Zhao, J.

作者： Zhao, J.;Yao, H.;Bao, G.;Zhao, J.;Pan, L.;Liu, Y.;Bao, G.;He, L.

作者机构：

关键词： atypical enteropathogenic Escherichia coil;bacteriophage;phage therapy;rabbit

期刊名称：WORLD RABBIT SCIENCE （ 影响因子：1.233； 五年影响因子：1.018 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： Pathogenic Escherichia coli (E. coil) is severely threatening the rabbit industry in China, and the concern over antibiotic-resistant bacteria has given rise to an urgent need for antibiotic alternatives. In this study, a member (ZRP1) of the Myoviridae family was isolated from rabbit faeces using a strain of rabbit atypical enteropathogenic E. coil (ZR1) as host. The one-step growth curve indicated that the latent period was around 25 to 30 min and the burst size was 144 +/- 31 plaque-forming unit/cell. The rate of phage-resistant mutation was 7x10(-5)+/- 4x10(-5). When the bacteriophage input at the multiplicity of infection (MOI) was 0.1, 1 or 10, the growth of host E. coil in broth was inhibited for 5 h. A single intravenous injection of ZRP1 at MOI 0.1, 1 or 10 significantly prolonged the survival time of rabbits which simultaneously received a lethal dose of ZR1.

分类号： S829.1

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