Flaxseed Oil Alleviates Chronic HFD-Induced Insulin Resistance through Remodeling Lipid Homeostasis in Obese Adipose Tissue
文献类型: 外文期刊
第一作者: Yu, Xiao
作者: Yu, Xiao;Shen, Ruiling;Yu, Xiao;Shen, Ruiling;Tang, Yuhan;Liu, Peiyi;Xiao, Lin;Liu, Liegang;Yao, Ping;Tang, Yuhan;Liu, Peiyi;Xiao, Lin;Liu, Liegang;Yao, Ping;Deng, Qianchun;Deng, Qianchun;Deng, Qianchun
作者机构:
关键词: flaxseed oil;insulin resistance;adipose tissue lipolysis;ATMs metabolic activation;hypoxia
期刊名称:JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY ( 影响因子:5.279; 五年影响因子:5.269 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: Emerging evidence suggests that higher circulating long-chain n-3 polyunsaturated fatty acids (n-3PUFA) levels were intimately associated with lower prevalence of obesity and insulin resistance. However, the understanding of bioactivity and potential mechanism of a-linolenic acid-rich flaxseed oil (ALA-FO) against insulin resistance was still limited. This study evaluated the effect of FO on high-fat diet (HFD)-induced insulin resistance in C57BL/6J mice focused on adipose tissue lipolysis. Mice after HFD feeding for 16 weeks (60% fat-derived calories) exhibited systemic insulin resistance, which was greatly attenuated by medium dose of FO (M-FO), paralleling with differential accumulation of ALA and its n-3 derivatives across serum lipid fractions. Moreover, M-FO was sufficient to effectively block the metabolic activation of adipose tissue macrophages (ATMs), thereby improving adipose tissue insulin signaling. Importantly, suppression of hypoxia-inducible factors HIF-l alpha and HIF-2 alpha were involved in FO-mediated modulation of adipose tissue lipolysis, accompanied by specific reconstitution of n-3PUFA within adipose tissue lipid fractions.
分类号: R15`S
- 相关文献
作者其他论文 更多>>
-
Flaxseed protein isolates-stabilized oil-water interface: Role of globulin and albumin
作者:Yang, Jing;Shao, Jiaqi;Peng, Dengfeng;Deng, Qianchun;Yang, Jing;Shao, Jiaqi;Peng, Dengfeng;Deng, Qianchun;Yang, Jing;Li, Dapeng;Duan, Yuqing;Zhang, Haihui;Ashokkumar, Muthupandian
关键词:Flaxseed protein fractions; Structure properties; Interfacial behavior; Oil-water interface
-
An enhancer-promoter-transcription factor module orchestrates plant immune homeostasis by constraining camalexin biosynthesis
作者:Zhang, Ying;Tang, Meng;Cheng, Qinglin;Xie, Jiatao;Cheng, Jiasen;Li, Bo;Jiang, Daohong;Yu, Xiao;Zhang, Ying;Tang, Meng;Cheng, Qinglin;Xie, Jiatao;Cheng, Jiasen;Fu, Yanping;Li, Bo;Jiang, Daohong;Yu, Xiao;Zhang, Ying;Tang, Meng;Cheng, Qinglin;Chen, Wei;Xie, Jiatao;Li, Bo;Jiang, Daohong;Yu, Xiao;Chen, Wei;Chen, Wei;Zhang, Yi;Liu, Lijiang
关键词:plant innate immunity; enhancers; antifungal resistance; transcriptional regulation; cis-regulatory ele-ments; transcription factors
-
Unraveling the microecological mechanisms of phosphate-solubilizing Pseudomonas asiatica JP233 through metagenomics: insights into the roles of rhizosphere microbiota and predatory bacteria
作者:Tang, Yuhan;Wang, Linlin;Fu, Jing;Zhou, Fangyuan;Wu, Xiaoqing;Fan, Susu;Zhang, Xinjian;Wei, Hailei
关键词:phosphate-solubilizing bacteria;
Pseudomonas asiatica ; soil P cycling; metagenomics; predatory bacteria -
A Hypovirulence-Associated Partitivirus and Re-Examination of Horizontal Gene Transfer Between Partitiviruses and Cellular Organisms
作者:Ye, Ting;Li, Han;Hai, Du;Zhaxi, Zhima;Duan, Jie;Xie, Jiatao;Cheng, Jiasen;Li, Bo;Chen, Tao;Yu, Xiao;Lyu, Xueliang;Xiao, Xueqiong;Jiang, Daohong;Ye, Ting;Li, Han;Hai, Du;Zhaxi, Zhima;Duan, Jie;Lin, Yang;Xie, Jiatao;Cheng, Jiasen;Li, Bo;Chen, Tao;Yu, Xiao;Lyu, Xueliang;Xiao, Xueqiong;Fu, Yanping;Jiang, Daohong;Ye, Ting
关键词:
Sclerotinia sclerotiorum ; mycoviruses; hypovirulence; horizontal gene transfer; partitivirus; coat protein; RdRP; cellular evolution -
A promising perspective to boost the utilizability of oil bodies: Moderate regulation and modification of interface
作者:Zhang, Shan;Zheng, Ruofan;Yu, Xiao;Chen, Yashu;Deng, Qianchun;Mcclements, David Julian;Yu, Xiao;Zhang, Shan;Sun, Zhida;Xie, Bijun
关键词:gastrointestinal tract; interfacial structure; oil body; physicochemical stability
-
Chemical and physical characterization, stability and antioxidant activity of avicularin/(2-hydroxypropyl)-p-cyclodextrin inclusion complex
作者:Zhu, Xiaoai;Xi, Jun;Liu, Kunlun;Zhu, Xiaoai;Cao, Yong;Feng, Konglong;Zhu, Xiaoai;Deng, Qianchun;Xiang, Xia;Gao, Zili;Xiao, Hang
关键词:Avicularin; (2-Hydroxypropyl)-p-cyclodextrin; Molecular docking; Antioxidant ability
-
Accelerated Biological Aging, Genetic Susceptibility, and Non-Alcoholic Fatty Liver Disease: Two Prospective Cohort Studies
作者:Zhao, Ying;He, Yuefeng;Zhao, Ying;Wang, Yu;Chen, Huimin;Tang, Yuhan;Yao, Ping;Zhao, Ying;Wang, Yu;Chen, Huimin;Tang, Yuhan;Yao, Ping;Chen, Li;Chen, Li
关键词:biological aging; KDMAge; PhenoAge; non-alcoholic fatty liver disease; polygenic risk score; genetic susceptibility