Cold adaptation in pigs depends on UCP3 in beige adipocytes

文献类型： 外文期刊

第一作者： Lin, Jun

作者： Lin, Jun;Ye, Rongcai;Dong, Meng;Jiang, Xiaoxiao;Jin, Wanzhu;Lin, Jun;Ye, Rongcai;Dong, Meng;Zheng, Qiantao;Jiang, Xiaoxiao;Cao, Chunwei;Zheng, Qiantao;Qin, Guosong;Zhao, Jianguo;Tao, Cong;Wang, Chao;Li, Kui;Wang, Yanfang;Yan, Changguo;Speakman, John R.;Jin, Wanzhu;Zhao, Jianguo

作者机构：

关键词： cold resistant;brown adipose tissue;beige adipocyte;Tibetan pig;thermogenesis

期刊名称：JOURNAL OF MOLECULAR CELL BIOLOGY （ 影响因子：6.216； 五年影响因子：6.688 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Pigs lack functional uncoupling protein 1 (UCP1) making them susceptible to cold. Nevertheless, several pig breeds are known to be cold resistant. The molecular mechanism(s) enabling such adaptation are currently unknown. Here, we show that this resistance is not dependent on shivering, but rather depends on UCP3 and white adipose tissue (WAT) browning. In two cold-resistant breeds (Tibetan and Min), but not a cold-sensitive breed (Bama), WAT browning was induced after cold exposure. Beige adipocytes from Tibetan pigs exhibited greater oxidative capacity than those from Bama pigs. Notably, UCP3 expression was significantly increased only in cold-resistant breeds, and knockdown of UCP3 expression in Tibetan adipocytes phenocopied Bama adipocytes in culture. Moreover, the eight dominant pig breeds found across China can be classified into cold-sensitive and cold-resistant breeds based on the UCP3 cDNA sequence. This study indicates that UCP3 has contributed to the evolution of cold resistance in the pig and overturns the orthodoxy that UCP1 is the only thermogenic uncoupling protein.

分类号： R393

  • 相关文献

[1]AMPK alpha 1 deficiency suppresses brown adipogenesis in favor of fibrogenesis during brown adipose tissue development. Zhao, Junxing,Du, Min,Zhao, Junxing,Yang, Qiyuan,Zhang, Lupei,Liang, Xingwei,Wang, Bo,Chen, Yanting,Du, Min,Sun, Xiaofei,Zhang, Lupei. 2017

[2]Anthocyanin-rich Aronia melanocarpa extract improves body temperature maintenance in healthy women with a cold constitution. Aoi, Wataru,Sonoda, Keisuke,Iwata, Tomoaki,Li, Yanmei. 2013

[3]Cidea controls lipid droplet fusion and lipid storage in brown and white adipose tissue. Wu LiZhen,Zhou LinKang,Gong JingYi,Li Peng,Wu LiZhen,Zhou LinKang,Gong JingYi,Li Peng,Chen Cheng,Xu Li,Ye Jing,Li De. 2014

[4]Changes in white and brown adipose tissue microRNA expression in cold-induced mice. Tao, Cong,Qi, Desheng,Tao, Cong,Huang, Shujuan,Wang, Yajun,Zhang, Yang,Wang, Yanfang,Li, Kui,Wei, Gang.

[5]Pig has no uncoupling protein 1. Hou, Lianjie,Shi, Jia,Cao, Lingbo,Xu, Guli,Wang, Chong,Hu, Chingyuan.

作者其他论文 更多>>

微信小程序