Marburg virus-like particles produced in insect cells induce neutralizing antibodies in rhesus macaques

文献类型: 外文期刊

第一作者: Gai Weiwei

作者: Gai Weiwei;Gai Weiwei;Zhao Yongkun;Wang Qi;Wang Hualei;Xie Ying;Wang Haijun;Cao Zengguo;Feng Na;Chi Hang;Wang Tiecheng;Gao Yuwei;Yang Songtao;Xia Xianzhu;Zheng Xuexing;Wang Chong;Wang Qi;Wong Gary;Shan Junjie

作者机构:

关键词: immune response;Marburg virus;nonhuman primates;vaccine;VLPs

期刊名称:JOURNAL OF MEDICAL VIROLOGY ( 影响因子:2.327; 五年影响因子:2.075 )

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收录情况: SCI

摘要: Marburg virus (MARV), which is one of the most virulent agents in the world, causes lethal haemorrhagic fever in humans and nonhuman primates (NHPs) with a mortality rate of up to 90%. Currently, there is no effective treatment or approved vaccine for MARV for human use to control disease outbreak and spread. Virus-like particles (VLPs), which are morphologically identical to the native infectious virus particle, are efficacious as vaccines against many viruses, including human papilloma virus (HPV), porcine circovirus (PCV) type 2 and hepatitis B virus (HBV). In this study, we generated MARV virus-like particles (VLPs) by co-expressing a glycoprotein (GP) and matrix protein (VP40) using the baculovirus expression system. Rhesus macaques vaccinated with MARV VLPs mixed with adjuvant Poria cocos polysaccharides (PCP-II) produced a GP-specific IgG titer of up to 1:1280 and virus-neutralizing antibody titers that reached 1:320. MARV VLPs also elicited interferon-gamma(IFN-gamma) and interleukin-4 (IL-4) secretion associated with T-helper 1 cell (Th1)- and T-helper 2 cell (Th2)-mediated immunity, as detected using enzyme-linked immunospot (ELISpot) assays. These data indicate that MARV VLPs mixed with adjuvant PCP-II have excellent immunogenicity in rhesus macaques and may be a promising candidate vaccine against MARV.

分类号: R37

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