Protective Effect of Selenium on Aflatoxin B1-Induced Testicular Toxicity in Mice

文献类型： 外文期刊

第一作者： Cao, Zheng

作者： Cao, Zheng;Shao, Bing;Xu, Feibo;Liu, Yunfeng;Li, Yanfei;Zhu, Yanzhu

作者机构：

关键词： Selenium;Aflatoxin B1;Testicular toxicity;Testosterone;Oxidative stress

期刊名称：BIOLOGICAL TRACE ELEMENT RESEARCH （ 影响因子：3.738； 五年影响因子：3.44 ）

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年卷期：

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收录情况： SCI

摘要： Abstract Aflatoxins have been considered as one of the major risk factors of male infertility, and aflatoxin B1 (AFB1) is the most highly toxic and prevalent member of the aflatoxins family. Selenium (Se), an essential nutritional trace mineral for normal testicular development and male fertility, has received extensive intensive on protective effects of male reproductive system due to its potential antioxidant and activating testosterone synthesis. To investigate the protective effect of Se on AFB1-induced testicular toxicity, the mice were orally administered with AFB1 (0.75?mg/kg) and Se (0.2?mg/kg or 0.4?mg/kg) for 45?days. We found that that Se elevated testes index, sperm functional parameters (concentration, malformation, and motility), and the level of serum testosterone in AFB1-exposed mice. Moreover, our results showed that Se attenuated the AFB1-induced oxidative stress and the reduction of testicular testosterone synthesis enzyme protein expression such as steroidogenic acute regulatory protein (StAR), P450 side-chain cleavage (P450scc), and 17β-hydroxysteroid dehydrogenase (17β-HSD) in AFB1-exposed mice. These results demonstrated that Se conferred protection against AFB1-induced testicular toxicity and can be attributed to its antioxidant and increased testosterone level by stimulating protein expression of StAR and testosterone synthetic enzymes.

分类号： Q5

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