The application of chiral ultra-high-performance liquid chromatography tandem mass spectrometry to the separation of the zoxamide enantiomers and the study of enantioselective degradation process in agricultural plants

文献类型： 外文期刊

第一作者： Dong, Fengshou

作者： Dong, Fengshou;Chen, Zenglong;Xu, Jun;Liu, Xingang;Wu, Xiaohu;Zheng, Yongquan

作者机构：

关键词： Zoxamide;Enantioselective separation;Enantioselective dissipation;Absolute configuration

期刊名称：JOURNAL OF CHROMATOGRAPHY A （ 影响因子：4.759； 五年影响因子：4.302 ）

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收录情况： SCI

摘要： Highlights?The enantioseparation method of zoxamide was firstly developed.?The absolute configuration of zoxamide enantiomers were determined through ECD.?The QuEChERS method was used to extract zoxamide in 8 kind of matrices.?The enantioselective dissipation were investigated in agricultural plants.?The direction of enantioselectivity depends on plant species.AbstractIn this study, an effective and sensitive chiral analytical method was developed to detect zoxamide enantiomers in vegetables, fruits and environmental matrices using ultra-high-performance liquid chromatography-tandem mass spectrometry. Optimal separation conditions were achieved with Lux Amylose-2 chiral column using acetonitrile/water (70:30v/v) as mobile phase with a flow rate and column temperature of 0.5mL/min and 25°C. The absolute configuration, optical rotation and elution order were confirmed for the first time. The average recoveries in all matrices at four spiking levels (0.5, 5, 50, 250μg/kg) ranged from 89.7 to 117.4%, with relative standard deviations being less than 10.9% for two enantiomers. The enantioselective dissipation of zoxamide in tomato showed that (?)-R-zoxamide was preferentially degraded leading to an enrichment of (+)-S-isomer, with half-lives of 3.80 d and 5.17 d, respectively. Inversely, (+)-S-zoxamide degraded faster than (?)-R-zoxamide in pepper (1.95day and 2.28day, respectively) and grape (2.03day and 2.87day). No significant enantioselectivity was observed in cucumber. The results of this study could help facilitate more accurate risk assessments of zoxamide in the future.]]>

分类号： O65

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