The down-regulation of casein kinase 1 alpha as a host defense response against infectious bursal disease virus infection

文献类型： 外文期刊

第一作者： Zhang, Lizhou

作者： Zhang, Lizhou;Li, Hui;Chen, Yuming;Gao, Xiang;Lu, Zhen;Gao, Li;Wang, Yongqiang;Gao, Yulong;Gao, Honglei;Liu, Changjun;Cui, Hongyu;Zhang, Yanping;Pan, Qing;Qi, Xiaole;Wang, Xiaomei;Wang, Xiaomei

作者机构：

关键词： IBDV;VP2;CK1α;IFNAR1;Host defense;Viral replication

期刊名称：VIROLOGY （ 影响因子：3.616； 五年影响因子：3.967 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Abstract Infectious bursal disease virus (IBDV) is an important immunosuppressive virus of chickens. Although the gene functions of IBDV have been well characterized, the host responses during IBDV infection remain much poor. In the present study, casein kinase 1 alpha (CK1α), a novel VP2-associated protein, was down-regulated during IBDV replication in DF1 cells. Further experiments showed that siRNA-mediated knockdown of CK1α inhibited IBDV replication, while overexpression of CK1α promoted IBDV growth. Finally, we revealed that the effects of CK1α expression level on IBDV replication were involved in the negative regulation of CK1α on type I interferon receptor (IFNAR1), because ubiquitination assay analyses demonstrated that CK1α could promote the ubiquitination of IFNAR1, thereby affecting the stability of this receptor. In conclusion, down-regulation of CK1α during IBDV infection as a host defense response increased abundance of IFNAR1, which in turn enhanced an inhibitory effect on IBDV replication. Highlights ? Host protein CK1α associates with IBDV VP2. ? Down-regulation of CK1α as a host response is triggered by the IBDV infection. ? Down-regulation of CK1α inhibits IBDV replication via increasing abundance expression of interferon receptor subunit IFNAR1.

分类号： R37

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