Ammonia exposure-triggered redox imbalance with the occurrence of inflammatory response, cell apoptosis, and the circadian clock disturbance leads to lung injury in growing pigs

文献类型： 外文期刊

第一作者： Tang, Shanlong

作者： Tang, Shanlong;Liu, Zhengqun;Deng, Fuli;Xu, Ye;Zhong, Ruqing;Chen, Liang;Zhang, Hongfu;Liu, Zhengqun

作者机构：

关键词： Ammonia; Oxidative stress; Inflammation; Apoptosis; Circadian clock

期刊名称：AIR QUALITY ATMOSPHERE AND HEALTH （ 影响因子：2.9； 五年影响因子：3.4 ）

ISSN： 1873-9318

年卷期： 2024 年

页码：

收录情况： SCI

摘要： The toxic impact of relatively low ammonia exposure on animal lungs lacks attention. Therefore, we employed pigs as an animal model to explore the effects and potential mechanisms of low (LA) and medium (MA) levels of ammonia exposure on lungs. The results demonstrated that the alterations of Th17 and chemokine expression worked through the NF-kappa B and JAK-STAT pathway to accelerate the imbalance of Th1/Th2 and the process of antigen processing and presentation, resulting in lung injury, inflammation and apoptosis. The cell proliferation was stimulated by increasing the expression of key cell cycle-related genes and enhancing cell cycle processes. Accordingly, ammonia exposure affected the cytochromes P450 system and ammonia metabolism within the pulmonary system accompanied by oxidative stress activation to exacerbate the inflammatory response. Furthermore, ammonia exposure inhibited the expression of BMAL1 by activating PER1/CRY1 with increased NFIL expression in MA pigs and activating PER1/2 with increased Rev-Erb or DBP expression in LA pigs, ultimately disrupting the circadian rhythm in pig lungs. Overall, oxidative stress-mediated inflammation and cell apoptosis caused by ammonia exposure were identified as the primary factors contributing to lung injury, which were associated with circadian clock disturbance.

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