Analysis of immune-related microRNAs in Bovine milk exosomes and construction of their regulatory networks

文献类型： 外文期刊

第一作者： Wang, Lele

作者： Wang, Lele;Wang, Gaofeng;Zhao, Meng;Tian, Rugang;Tian, Rugang

作者机构：

关键词： Bovine colostrum; exosomal miRNA; immunity; regulatory network

期刊名称：JOURNAL OF APPLIED ANIMAL RESEARCH （ 影响因子：1.9； 五年影响因子：1.9 ）

ISSN： 0971-2119

年卷期： 2025 年 53 卷 1 期

页码：

收录情况： SCI

摘要： Bovine colostrum is rich in many immune components. Milk exosomes are secreted by mammary epithelial cells and contain proteins, nucleic acids, microRNAs (miRNAs) and other bioactive substances related to immune response and growth. MiRNAs are short non-coding RNAs (ncRNA)with various biological functions through translational inhibition or mRNA destabilisation. Mature miRNAs are involved in various regulatory pathways, including development, viral defense, cell proliferation and apoptosis, and fat metabolism. MiRNA sequencing of bovine colostrum and milk exosomes was performed, and the miRNA and mRNA data were jointly analyzed. The results suggest that bta-miR-19b, bta-miR-186 and bta-miR-151-5p may be key miRNAs associated with the immune function of bovine colostrum exosomes. Target gene prediction revealed that miRNAs are involved in multiple signalling pathways through target genes such as IL1R1, BOLA-DOA, MAP3K1, MAPK8, RELA and TNF. Our results indicate that specific miRNAs and their target genes likely contribute to immune regulation, yet the exact molecular mechanisms governing these interactions remain to be fully elucidated.

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