Insight into pyrrolizidine alkaloids degradation and the chemical structures of their degradation products using ultra high performance liquid chromatography and Q-Exactive Orbitrap mass spectrometry

文献类型： 外文期刊

第一作者： Yi, Yuexing

作者： Yi, Yuexing;Wang, Ziqi;Li, Shiqi;Li, Zuguang;Yi, Yuexing;Lu, Yuting;Liu, Hongxia;Wang, Ziqi;Li, Shiqi;Huang, Xuchen;Chai, Yunfeng;Zhang, Xiangchun;Chen, Hongping;Lu, Yuting;Liu, Hongxia;Huang, Xuchen;Chai, Yunfeng;Zhang, Xiangchun;Chen, Hongping

作者机构：

关键词： PAs; Photolysis; UHPLC Q-Exactive Orbitrap MS; Degradation products; Toxicity

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：13.6； 五年影响因子：12.7 ）

ISSN： 0304-3894

年卷期： 2024 年 471 卷

页码：

收录情况： SCI

摘要： Pyrrolizidine alkaloids (PAs), released into the environment by donor plants, are absorbed by crops or transported by animals, posing a global food safety concern. Photolysis is an effective way to eliminate harmful substances in the environment or food. Photolysis happens as PAs move among plants, environment and crops. In this study, we first investigated the photolysis and hydrolysis of 15 PAs and identified their degradation products via ultra -high performance liquid chromatography and Q-Exactive Orbitrap mass spectrometry. PAs were degraded under UV radiation but minimally affected by visible light from a xenon lamp, and solvent pH had little impact on their photolysis. PAs were stable in neutral and acidic solutions but degraded by 50% within 24 h in alkaline conditions. The degradation products of PAs were mainly PAs/PANOs isomers and some minor byproducts. Cytotoxicity and computational analysis revealed isomers had similar toxicity, with minor products being less toxic. This study is a precursor for revealing the potential PAs degradation dynamics in the environment and food products, providing a reference for systematic evaluations of potential health and ecological risks of their degradation products.

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