Effects of the bioconcentration and parental transfer of environmentally relevant concentrations of difenoconazole on endocrine disruption in zebrafish (Danio rerio)

文献类型: 外文期刊

第一作者: Teng, Miaomiao

作者: Teng, Miaomiao;Zhu, Wentao;Wang, Yao;Wang, Dezhen;Wang, Chengju;Qi, Suzhen;Dong, Kai

作者机构:

关键词: Difenoconazole;Zebrafish;Bioaccumulation;Endocrine disruption;Parental transfer

期刊名称:ENVIRONMENTAL POLLUTION ( 影响因子:8.071; 五年影响因子:8.35 )

ISSN: 0269-7491

年卷期: 2018 年 233 卷

页码:

收录情况: SCI

摘要: Difenoconazole, a typical triazole fungicide, inhibits lanosterol-14R-demethylase (CYP51) to prevent fungal sterol synthesis and its residues are frequently detected in the environment due to its wide application. Previous studies have demonstrated that difenoconazole altered the triglyceride levels, and gene expression relevant to cholesterol biosynthesis in zebrafish. However, endocrine-disruption in the hypothalamus-pituitary-gonadal-liver (HPGL) axis, the effects of transferring to offspring, and the underlying mechanisms of difenoconazole in aquatic organisms are still unknown. In this study, we defined the effects of difenoconazole at environmental concentrations on endocrine disturbance using zebrafish as an experimental model. The results indicated that difenoconazole induced a significant change in the somatic index, and pathological variations in tissues, and steroid hormone levels. RT-PCR experiments further confirmed that difenoconazole significantly induced expression alteration of lhr, hsd3 beta, hsd11 beta, cyp19a in the ovary and star, cyp19a, cyp3c1 in the testis, and er alpha genes in livers. In addition, difenoconazole exposure in parental zebrafish affected the hatchability and length of its offspring. Moreover, the burdens of difenoconazole and difenoconazole alcohol in females were higher than in males. These findings highlighted that difenoconazole exposure at environmentally relevant concentrations elicited estrogenic endocrine-disruption effects via altering homeostasis of sex steroid hormones in the HPGL axis and the adverse effects can be transferred to the offspring. (C) 2017 Elsevier Ltd. All rights reserved.

分类号:

  • 相关文献

[1]Effects of azocyclotin on gene transcription and steroid metabolome of hypothalamic-pituitary-gonad axis, and their consequences on reproduction in zebrafish (Danio rerio). Ma, You-Ning,Cao, Chu-Yan,Wang, Qiang-Wei,Gui, Wen-Jun,Zhu, Guo-Nian,Ma, You-Ning.

[2]Pretilachlor has the potential to induce endocrine disruption, oxidative stress, apoptosis and immunotoxicity during zebrafish embryo development. Jiang, Jinhua,Chen, Yanhong,Yu, Ruixian,Zhao, Xueping,Wang, Qiang,Cai, Leiming. 2016

[3]Effect of acetochlor on transcription of genes associated with oxidative stress, apoptosis, immunotoxicity and endocrine disruption in the early life stage of zebrafish. Jiang, Jinhua,Wu, Shenggan,Liu, Xinju,Wang, Yanhua,An, Xuehua,Cai, Leiming,Zhao, Xueping.

[4]Embryonic exposure to carbendazim induces the transcription of genes related to apoptosis, immunotoxicity and endocrine disruption in zebrafish (Danio rerio). Jiang, Jinhua,Wu, Shenggan,Wu, Changxing,An, Xuehua,Cai, Leiming,Zhao, Xueping,Jiang, Jinhua,Wu, Shenggan,Wu, Changxing,An, Xuehua,Cai, Leiming,Zhao, Xueping.

[5]Metabolomics and transcriptomics reveal the toxicity of difenoconazole to the early life stages of zebrafish (Danio rerio). Teng, Miaomiao,Zhu, Wentao,Wang, Dezhen,Wang, Yao,Yan, Jin,Zheng, Mingqi,Wang, Chengju,Qi, Suzhen,Dong, Kai. 2018

[6]Sex-specific effects of difenoconazole on the growth hormone endocrine axis in adult zebrafish (Danio rerio). Teng, Miaomiao,Zhu, Wentao,Wang, Yao,Wang, Dezhen,Yang, Yang,Li, Hui,Li, Chenglong,Wang, Chengju,Qi, Suzhen,Dong, Kai. 2017

[7]The developmental effect of difenoconazole on zebrafish embryos: A mechanism research. Mu, Xiyan,Chai, Tingting,Zhu, Lizhen,Li, Xuefeng,Wang, Chengju,Mu, Xiyan,Huang, Ying,Shen, Gongming,Li, Yingren,Wang, Kai.

[8]Chiral bioaccumulation behavior of tebuconazole in the zebrafish (Danio rerio). Liu, Na,Dong, Fengshou,Xu, Jun,Liu, Xingang,Zheng, Yangquan.

[9]Physiological responses and gene expression changes in the western mosquitofish (Gambusia affinis) exposed to progesterone at environmentally relevant concentrations. Hou, Liping,Yang, Yang,Shu, Hu,Cheng, Xuemei,Xu, Hongyan,Ying, Guangguo,Zhao, Jianliang,Ying, Guangguo,Zhao, Jianliang. 2017

[10]Toxicological analysis of triadimefon on endocrine disruption and oxidative stress during rare minnow (Gobiocypris rarus) larvae development. Jiang, Jinhua,Hu, Gaojie,Zhang, Changpeng,Zhao, Xueping,Wang, Qiang,Chen, Liezhong. 2017

[11]Quizalofop-P-ethyl exposure increases estrogen axis activity in male and slightly decreases estrogen axis activity in female zebrafish (Danio rerio). Zhu, Li-Zhen,Qi, Su-Zhen,Cao, Fang-Jie,Mu, Xi-Yan,Yang, Yang,Wang, Chengju,Qi, Su-Zhen,Mu, Xi-Yan.

[12]Carbendazim has the potential to induce oxidative stress, apoptosis, immunotoxicity and endocrine disruption during zebrafish larvae development. Jiang, Jinhua. 2015

[13]Determination of difenoconazole residue in tomato during home canning by UPLC-MS/MS. Dong, Fengshou,Xu, Jun,Liu, Xingang,Li, Jing,Li, Yuanbo,Chen, Xiu,Zheng, Yongquan,Zhang, Changpeng,Shan, Weili. 2012

[14]Simultaneous enantioselective determination of triazole fungicide difenoconazole and its main chiral metabolite in vegetables and soil by normal-phase high-performance liquid chromatography. Dong, Fengshou,Cheng, Youpu,Liu, Xingang,Xu, Jun,Li, Yuanbo,Chen, Xiu,Kong, Zhiqiang,Zheng, Yongquan,Cheng, Youpu.

[15]Concentrations and dissipation of difenoconazole and fluxapyroxad residues in apples and soil, determined by ultrahigh-performance liquid chromatography electrospray ionization tandem mass spectrometry. Jia, Chunhong,Zhao, Ercheng,Chen, Li,Yu, Pingzhong,Jing, Junjie,He, Min,Zheng, Yongquan.

[16]Comparison of Greenhouse and Field Degradation Behaviour of Isoprocarb, Hexaflumuron and Difenoconazole in Perilla frutescens. Sun, Caixia,Zhang, Hu,Tang, Tao,Qian, Mingrong,Yuan, Yuwei,Zhang, Zhiheng,Sun, Caixia,Zhang, Hu,Tang, Tao,Qian, Mingrong,Yuan, Yuwei,Zhang, Zhiheng,Sun, Caixia,Zhang, Hu,Tang, Tao,Qian, Mingrong,Yuan, Yuwei,Zhang, Zhiheng.

[17]Residue Determination of Epoxiconazole, Indoxacarb and Difenoconazole in Tea, Tea Infusion and Soil using Ultra High Performance Liquid Chromatography Coupled with Tandem Mass Spectrometry. Zhang Xin-Zhong,Luo Feng-Jian,Chen Zong-Mao,Liu Guang-Ming,Lou Zheng-Yun,Wang Fang,Wu Lu-Chao,Zhang Xin-Zhong,Luo Feng-Jian,Chen Zong-Mao,Liu Guang-Ming,Lou Zheng-Yun,Zhang Xin-Zhong,Luo Feng-Jian,Chen Zong-Mao,Liu Guang-Ming,Lou Zheng-Yun. 2013

[18]Dissipation and Residues of Difenoconazole and Azoxystrobin in Bananas and Soil in Two Agro-Climatic Zones of China. Huan, Zhibo,Xu, Zhi,Lv, Daizhu,Xie, Defang,Luo, Jinhui.

[19]Degradation of three fungicides following application on strawberry and a risk assessment of their toxicity under greenhouse conditions. Sun, Caixia,Cang, Tao,Wang, Zhiwei,Wang, Xinquan,Yu, Ruixian,Wang, Qiang,Zhao, Xueping.

[20]Degradation of four fungicides in tropical soils from Hainan, China. Han, Bing Jun,Peng, Li Xu,Chen, Li Xia.

作者其他论文 更多>>