Altered Serum Metabolite Profiling and Relevant Pathway Analysis in Rats Stimulated by Honeybee Venom: New Insight into Allergy to Honeybee Venom

文献类型: 外文期刊

第一作者: Zhao, Yazhou

作者: Zhao, Yazhou;Li, Zhiguo;Nie, Hongyi;Su, Songkun;Zhao, Yazhou;Zhang, Jianmei;Peng, Wenjun;Chen, Yanping

作者机构:

关键词: honeybee venom stimulation;serum metabonomics;metabolite profiling;H-1 NMR

期刊名称:JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY ( 影响因子:5.279; 五年影响因子:5.269 )

ISSN: 0021-8561

年卷期: 2018 年 66 卷 4 期

页码:

收录情况: SCI

摘要: To improve our understanding of the disturbed metabolic pathways and cellular responses triggered by honeybee venom stimulation, we compared the changes in serum metabolites in rats, either stimulated or not by honeybee venom, by performing H-1 nuclear magnetic resonance (NMR) spectrometry-based metabonomics to identify potential biomarkers. In this study, 65 metabolites were structurally confirmed and quantified and the following results were obtained. First, by pattern recognition analysis, 14 metabolites were selected as potential biomarkers 3 h after venom stimulation. Second, metabolic pathway analysis showed that methane metabolism, glyoxylate and dicarboxylate metabolism, tricarboxylic acid cycle, glycine, serine, and threonine metabolism, arginine and proline metabolism were affected. Finally, the time-dependent metabolic modifications indicated that rats could recover without medical treatment 24 h after venom stimulation. In summary, this new insight into the changes in serum metabolites in rats after honeybee venom stimulation has enhanced our understanding of the response of an organism to honeybee venom.

分类号:

  • 相关文献

[1]Metabolite Profiling of Barley Grains Subjected to Water Stress: To Explain the Genotypic Difference in Drought-Induced Impacts on Malting Quality. Wu, Xiaojian,Cai, Kangfeng,Zhang, Guoping,Zeng, Fanrong,Wu, Xiaojian. 2017

[2]Identification of Conserved and Diverse Metabolic Shift of the Stylar, Intermediate and Peduncular Segments of Cucumber Fruit during Development. Hu, Chaoyang,Zhao, Huiyu,Wang, Wen,Xu, Mingfei,Yang, Guiling,Hu, Chaoyang,Shi, Jianxin,Nie, Xiangbo. 2018

[3]Comparison of the meat metabolite composition of Linwu and Pekin ducks using 600 MHz H-1 nuclear magnetic resonance spectroscopy. Wang, Xiangrong,Fang, Chengkun,He, Jianhua,Dai, Qiuzhong,Fang, Rejun,Wang, Xiangrong,Dai, Qiuzhong,Wang, Xiangrong,Dai, Qiuzhong.

[4]Integrated analysis of rice transcriptomic and metabolomic responses to elevated night temperatures identifies sensitivity- and tolerance-related profiles. Glaubitz, Ulrike,Li, Xia,Schaedel, Sandra,Erban, Alexander,Sulpice, Ronan,Kopka, Joachim,Hincha, Dirk K.,Zuther, Ellen,Li, Xia,Schaedel, Sandra,Sulpice, Ronan.

[5]Genetic background and environmental conditions drive metabolic variation in wild type and transgenic soybean (Glycine max) seeds. Cohen, Hagai,Yu, Yang,Hou, Wensheng,Sun, Shi,Han, Tianfu,Cohen, Hagai,Shir, Ofer M.,Amir, Rachel,Shir, Ofer M.,Amir, Rachel.

[6]Comparative Metabolite Profiling and Hormone Analysis of Perennial and Annual Rice. Zhao, Xiuqin,Zhang, Ting,Huang, Liyu,Wu, Huimin,Zhang, Fan,Zhu, Linghua,Fu, Binying,Zhang, Ting,Hu, Fengyi.

[7]Evaluation of sugar, free amino acid, and organic acid compositions of different varieties of vegetable soybean (Glycine max [L.] Merr). Song, Jiangfeng,Gu, Zhenxin,Song, Jiangfeng,Liu, Chunquan,Li, Dajing,Liu, Chunquan. 2013

[8]The effect of ultrafiltered fish protein hydrolysate levels on the liver and muscle metabolic profile of juvenile turbot (Scophthalmus maximus L.) by H-1 NMR-based metabolomics studies. Wei, Yuliang,Liang, Mengqing,Zheng, Keke,Xu, Houguo,Wei, Yuliang,Mai, Kangsen,Wei, Yuliang,Mai, Kangsen.

[9]Subacute oral toxicity assessment of benalaxyl in mice based on metabolomics methods. Wang, Xinru,Wang, Xinru,Wang, Dezhen,Zhou, Zhiqiang,Zhu, Wentao. 2018

[10]H-1 NMR-based metabolomics approach for understanding the fermentation behaviour of Bacillus licheniformis. Yan, Zheng,Zheng, Xiao-Wei,Han, Bei-Zhong,Yan, Yin-Zhuo,Chen, Jing-Yu,Yan, Zheng,Zheng, Xiao-Wei,Zhang, Xin.

[11]H-1 and C-13 assignments of two new macrocyclic lactones isolated from Streptomyces sp 211726 and revised assignments of Azalomycins F-3a, F-4a and F-5a. Yuan, Ganjun,Lin, Haipeng,Wang, Cheng,Hong, Kui,Yuan, Ganjun,Yuan, Ganjun,Hong, Kui,Liu, Yue,Li, Jia. 2011

[12]H-1 NMR-based metabolomics studies on the effect of size-fractionated fish protein hydrolysate, fish meal and plant protein in diet for juvenile turbot (Scophthalmus maximus L.). Wei, Y.,Mai, K.,Wei, Y.,Liang, M.,Zheng, K.,Xu, H..

[13]H-1 and C-13 NMR assignments of eight nitrogen containing compounds from Nocardia alba sp.nov (YIM 30243(T)). Ding, Zhang-Gui,Zhao, Jiang-Yuan,Yang, Pei-Wen,Li, Ming-Gang,Cui, Xiao-Long,Wen, Meng-Liang,Huang, Rong,Wen, Meng-Liang,Yang, Pei-Wen.

作者其他论文 更多>>