Comparative evaluation of three capripoxvirus-vectored peste des petits ruminants vaccines

文献类型： 外文期刊

第一作者： Fakri, F.

作者： Fakri, F.;Bamouh, Z.;Ghzal, F.;Baha, W.;Tadlaoui, K.;Elharrak, M.;Fakri, F.;Fihri, O. Fassi;Chen, W.;Bu, Z.;Chen, W.;Bu, Z.

作者机构： MCI Sante Anim, Res & Dev, Lot 157,BP 278, Mohammadia 28810, Morocco;Inst Agron & Vet Hassan II, Rabat, Morocco;Chinese Acad Agr Sci, Key Lab Vet Publ Hlth, Minist Agr, Harbin 150001, Heilongjiang, Peoples R China;Chinese Acad Agr Sci, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin 150001, Heilongjiang, Peoples R China

关键词： Capripoxvirus vector;Peste des petits ruminants (PPR);Sheep and goat pox (SGP);Recombinant vaccine

期刊名称：VIROLOGY （ 2020影响因子：3.616； 五年影响因子：3.967 ）

ISSN： 0042-6822

年卷期： 2018 年 514 卷

页码：

收录情况： SCI

摘要： Sheep and goat pox (SGP) with peste des petits ruminants (PPR) are transboundary viral diseases of small ruminants that cause huge economic losses. Recombinant vaccines that can protect from both infections have been reported as a promising solution for the future. SGP was used as a vector to express two structural proteins hemagglutinin or the fusion protein of PPRV. We compared immunity conferred by recombinant capripoxvirus vaccines expressing H or F or both HF. Safety and efficacy were evaluated in goats and sheep. Two vaccine doses were tested in sheep, 10(4.5)TCD150 in 1 ml dose was retained for the further experiment. Results showed that the recombinant HF confers an earlier and stronger immunity against both SGP and PPR. This recombinant vaccine protect also against the disease in exposed and unexposed sheep. The potential Differentiating Infected from Vaccinated Animals of recombinant vaccines is of great advantage in any eradication program.

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