Comprehensive Proteomic Analysis of Lysine Acetylation in the Foodborne Pathogen Trichinella spiralis
文献类型: 外文期刊
第一作者: Yang, Yong
作者: Yang, Yong;Bai, Xue;Liu, Xiaolei;Liu, Mingyuan;Yang, Yong;Zhang, Peihao;Cai, Wei;Tong, Mingwei;Cai, Xuepeng;Cai, Xuepeng;Luo, Xuenong;Vallee, Isabelle;Zhou, Yonghua
作者机构:
关键词: lysine acetylation;post-translational modification;lysine acetylation motif;interaction network;Trichinella spiralis
期刊名称:FRONTIERS IN MICROBIOLOGY ( 影响因子:5.64; 五年影响因子:6.32 )
ISSN: 1664-302X
年卷期: 2018 年 8 卷
页码:
收录情况: SCI
摘要: Lysine acetylation is a dynamic and highly conserved post-translational modification that plays a critical role in regulating diverse cellular processes. Trichinella spiralis is a foodborne parasite with a considerable socio-economic impact. However, to date, little is known regarding the role of lysine acetylation in this parasitic nematode. In this study, we utilized a proteomic approach involving anti-acetyl lysine-based enrichment and highly sensitive mass spectrometry to identify the global acetylated proteome and investigate lysine acetylation in T. spiralis. In total, 3872 lysine modification sites were identified in 1592 proteins that are involved in a wide variety of biological processes. Consistent with the results of previous studies, a large number of the acetylated proteins appear to be involved in metabolic and biosynthetic processes. Interestingly, according to the functional enrichment analysis, 29 acetylated proteins were associated with phagocytosis, suggesting an important role of lysine acetylation in this process. Among the identified proteins, 15 putative acetylation motifs were detected. The presence of serine downstream of the lysine acetylation site was commonly observed in the regions surrounding the sites. Moreover, protein interaction network analysis revealed that various interactions are regulated by protein acetylation. These data represent the first report of the acetylome of T. spiralis and provide an important resource for further explorations of the role of lysine acetylation in this foodborne pathogen.
分类号:
- 相关文献
作者其他论文 更多>>
-
Protective effect of a newly probiotic Lactobacillus reuteri LY2-2 on DSS-induced colitis
作者:Yang, Yong;Liu, Hongli;Tong, Mingwei;Yang, Yong;Qiao, Yuyu;Liu, Ge;Yi, Gaoqin;Tong, Mingwei;Yang, Yong;Qiao, Yuyu;Liu, Ge;Yi, Gaoqin;Tong, Mingwei;Zhang, Ting
关键词:Probiotics;
Lactobacillus reuteri ; Colitis; Intestinal inflammation; Gut microbiota -
Exploiting Response Surface Methodology to Engineer the Mechanical Properties of Alginate-based Hydrogels
作者:Bucciarelli, Alessio;Tirella, Annalisa;Zhao, Chen;Bai, Xue;Kay, Rebekah;Latif, Ayse;Williams, Kaye J.;Tirella, Annalisa;Bai, Xue
关键词:alginate; breast cancer models; hydrogels; oxidized alginate; response surface methodology
-
Global investigation into the CqCYP76AD and CqDODA families in Chenopodium quinoa: Identification, evolutionary history, and their functional roles in betalain biosynthesis
作者:Li, Li;Li, Xiao'an;Guo, Huihui;He, Cailin;Lu, Jing;Ye, Xueling;Sun, Wenjun;Liu, Changying;Fan, Yu;Bai, Xue;Wu, Qi;Wu, Qi;Gao, Xiaoli;Liao, Wenhua
关键词:Betalain biosynthesis; CqCYP76AD; CqDODA; Evolutionary history; CqCYP76AD-CqDODA operon; Hairy root transformation; Quinoa
-
Emergence of Canine Parvovirus Type 2a and Canine Enteric Coronavirus in Diarrheal Outbreaks Among Farmed Raccoon Dogs in China
作者:Lu, Rongguang;Yang, Wei;Qian, Tingli;Li, Guobao;Lu, Rongguang;Cao, Haixu;Fu, Jianhai;Zhang, Chengqi;Hu, Bo;Xu, Liwen;Li, Shuangshuang;Zhao, Guanyu;Bai, Xue;Feng, Na;Shi, Qiumei;Zang, Deyue
关键词:epidemiology; evolution; mixed infections; molecular characteristics; receptor interaction
-
Integrated analysis reveals that miR-548ab promotes the development of obesity and T2DM
作者:Pan, Chongge;Hou, Yanting;Qian, Meiyu;Liang, Maodi;Wang, Jingzhou;Liu, Jie;Wei, Qianqian;Pan, Ziyan;Wang, Ting;Hu, Chenyu;Wang, Cuizhe;Zhang, Jun;Pan, Chongge;Hou, Yanting;Qian, Meiyu;Liang, Maodi;Wang, Jingzhou;Liu, Jie;Wei, Qianqian;Pan, Ziyan;Wang, Ting;Hu, Chenyu;Wang, Cuizhe;Zhang, Jun;Hou, Yali;Wang, Ruizhen;Bai, Xue;Yang, Chun;Chen, Hua;Wang, Ruizhen;Bai, Xue;Yang, Chun;Chen, Hua;Wang, Ruizhen;Chen, Hua;Xiang, Kun;Chen, Hua
关键词:Obesity; miR-548ab; Glucose metabolism; T2DM
-
Temperature acclimation modulates stress, immunity, and apoptosis in juvenile Siberian hybrid sturgeon during simulated transport
作者:Jiang, Hongcheng;Wang, Juguang;Wang, Zhaoding;Bai, Chan;Xiong, Guangquan;Wang, Lan;Liao, Tao;Jiang, Hongcheng;Wang, Juguang;Wang, Zhaoding;Bai, Chan;Xiong, Guangquan;Wang, Lan;Liao, Tao;Jiang, Hongcheng;Chen, Jiaping;Cai, Wei;Cheng, Jun
关键词:Sturgeon; Transport; Temperature; Acclimation; Stress; Innate immunity
-
Haplotype-resolved and chromosome-level reference genome assembly of Diospyros deyangensis provides insights into the evolution and juvenile growth of persimmon
作者:Guan, Changfei;Liu, Yunxiao;Li, Zhongxing;Zhang, Yangxin;Liu, Zhiguang;Zhu, Qinggang;Shen, Xiaoxia;Fang, Jing;Li, Jiayan;Guan, Qingmei;Yang, Yong;Zhao, Tao;Guan, Changfei;Liu, Yunxiao;Zhang, Yangxin;Liu, Zhiguang;Zhu, Qinggang;Fang, Jing;Li, Jiayan;Guan, Qingmei;Yang, Yong;Zhao, Tao;Li, Zhongxing;Shen, Xiaoxia;Zhang, Pingxian;Zhang, Qingling;Luo, Zhengrong
关键词: