Epidermal growth factor promotes proliferation of dermal papilla cells via Notch signaling pathway

文献类型： 外文期刊

第一作者： Zhang, Haihua

作者： Zhang, Haihua;Wang, Shiyong;Zhang, Tietao;Wang, Datao;Yang, Fuhe;Li, Guangyu;Nan, Weixiao;Si, Huazhe

作者机构：

关键词： Epidermal growth factor;Dermal papilla;Hair follicle;Notch pathway

期刊名称：BIOCHIMIE （ 影响因子：4.079； 五年影响因子：4.104 ）

ISSN： 0300-9084

年卷期： 2016 年 127 卷

页码：

收录情况： SCI

摘要： The effect of epidermal growth factor (EGF) on the development and growth of hair follicle is controversial. In the present study, 2-20 ng/ml EGF promoted the growth of mink hair follicles in vitro, whereas 200 ng/ml EGF inhibited follicle growth. Further, dermal papilla (DP) cells, a group of mesenchymal cells that govern hair follicle development and growth, were isolated and cultured in vitro. Treatment with or forced expression of EGF accelerated proliferation and induced G(1)/S transition in DP cells. Moreover, EGF upregulated the expression of DP mesenchymal genes, such as alkaline phosphatase (ALP) and insulin like growth factor (IGF-1), as well as the Notch pathway molecules including Notch1, Jagged1, Hes1 and Hes5. In addition, inhibition of Notch signaling pathway by DAPT significantly reduced the basal and EGF-enhanced proliferation rate, and also suppressed cell cycle progression. We also show that the expression of several follicle-regulatory genes, such as Survivin and Msx2, were upregulated by EGF, and was inhibited by DAPT. In summary, our study demonstrates that the concentration of EGF is critical for the switch between hair follicle growth and inhibition, and EGF promotes DP cell proliferation via Notch signaling pathway. (C) 2016 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.

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