The known and missing links between Toxoplasma gondii and schizophrenia

文献类型： 外文期刊

第一作者： Elsheikha, Hany M.

作者： Elsheikha, Hany M.;Busselberg, Dietrich;Zhu, Xing-Quan

作者机构：

关键词： Toxoplasma gondii;Schizophrenia;Mental illness;Psychosis;Host-pathogen interaction

期刊名称：METABOLIC BRAIN DISEASE （ 影响因子：3.584； 五年影响因子：3.369 ）

ISSN： 0885-7490

年卷期： 2016 年 31 卷 4 期

页码：

收录情况： SCI

摘要： Toxoplasma gondii, an intracellular protozoan parasite, has a striking predilection for infecting the Central Nervous System and has been linked to an increased incidence of a number of psychiatric diseases. Several in vitro and in vivo studies have shown that T. gondii infection can affect the structure, bioenergetics and function of brain cells, and alters several host cell processes, including dopaminergic, tryptophan-kynurenine, GABAergic, AKT1, Jak/STAT, and vasopressinergic pathways. These mechanisms underlying the neuropathology of latent toxoplasmosis seem to operate also in schizophrenia, supporting the link between the two disorders. Better understanding of the intricate parasite-neuroglial communications holds the key to unlocking the mystery of T. gondii-mediated schizophrenia and offers substantial prospects for the development of disease-modifying therapies.

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