Genome-wide Association Study Identifies Loci for the Polled Phenotype in Yak

文献类型： 外文期刊

第一作者： Liang, Chunnian

作者： Liang, Chunnian;Wu, Xiaoyun;Chu, Min;Yan, Ping;Wang, Lizhong;Wang, Kun;Ding, Xuezhi;Wang, Mingcheng;Xie, Xiuyue;Qiu, Qiang

作者机构：

期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）

ISSN： 1932-6203

年卷期： 2016 年 11 卷 7 期

页码：

收录情况： SCI

摘要： The absence of horns, known as the polled phenotype, is an economically important trait in modern yak husbandry, but the genomic structure and genetic basis of this phenotype have yet to be discovered. Here, we conducted a genome-wide association study with a panel of 10 horned and 10 polled yaks using whole genome sequencing. We mapped the POLLED locus to a 200-kb interval, which comprises three protein-coding genes. Further characterization of the candidate region showed recent artificial selection signals resulting from the breeding process. We suggest that expressional variations rather than structural variations in protein probably contribute to the polled phenotype. Our results not only represent the first and important step in establishing the genomic structure of the polled region in yak, but also add to our understanding of the polled trait in bovid species.

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