MYH9 is an Essential Factor for Porcine Reproductive and Respiratory Syndrome Virus Infection

文献类型： 外文期刊

第一作者： Gao, Jiming

作者： Gao, Jiming;Xiao, Shuqi;Zhang, Chong;Zhao, Qin;Nan, Yuchen;Huang, Baicheng;Liu, Hongliang;Du, Taofeng;Sun, Yani;Mu, Yang;Syed, Shahid Faraz;Zhou, En-Min;Xiao, Yihong;Liu, Ningning;Lv, Junhua;Wang, Gang;Zhang, Gaiping;Hiscox, Julian A.;Goodfellow, Ian;Gao, Jiming;Wang, Xiangpeng;Liu, Ningning;Lv, Junhua

作者机构：

期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.379； 五年影响因子：5.133 ）

ISSN： 2045-2322

年卷期： 2016 年 6 卷

页码：

收录情况： SCI

摘要： Porcine reproductive and respiratory syndrome (PRRS) caused by the PRRS virus (PRRSV) is an important swine disease worldwide. PRRSV has a limited tropism for certain cells, which may at least in part be attributed to the expression of the necessary cellular molecules serving as the virus receptors or factors on host cells for virus binding or entry. However, these molecules conferring PRRSV infection have not been fully characterized. Here we show the identification of non-muscle myosin heavy chain 9 (MYH9) as an essential factor for PRRSV infection using the anti-idiotypic antibody specific to the PRRSV glycoprotein GP5. MYH9 physically interacts with the PRRSV GP5 protein via its C-terminal domain and confers susceptibility of cells to PRRSV infection. These findings indicate that MYH9 is an essential factor for PRRSV infection and provide new insights into PRRSV-host interactions and viral entry, potentially facilitating development of control strategies for this important swine disease.

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