Lactobacillus fermentum Suo Attenuates HCl/Ethanol Induced Gastric Injury in Mice through Its Antioxidant Effects

文献类型： 外文期刊

第一作者： Suo, Huayi

作者： Suo, Huayi;Sun, Baozhong;Suo, Huayi;Zhao, Xin;Qian, Yu;Sun, Peng;Zhu, Kai;Zhao, Xin;Qian, Yu;Sun, Peng;Zhu, Kai;Zhao, Xin;Qian, Yu;Sun, Peng;Zhu, Kai;Li, Jian

作者机构：

关键词： gastric injury;mice;Lactobacillus fermentum Suo;antioxidant;ethanol

期刊名称：NUTRIENTS （ 影响因子：5.717； 五年影响因子：6.349 ）

ISSN： 2072-6643

年卷期： 2016 年 8 卷 3 期

页码：

收录情况： SCI

摘要： The purpose of the study was to determine the inhibitory effects of Lactobacillus fermentum Suo (LF-Suo) on HCl/ethanol induced gastric injury in ICR (Institute for Cancer Research) mice and explain the mechanism of these effects through the molecular biology activities of LF-Suo. The studied mice were divided into four groups: healthy, injured, LF-Suo-L and LF-Suo-H group. After the LF-Suo intragastric administration, the gastric injury area was reduced compared to the injured group. The serum MOT (motilin), SP (substance P), ET (endothelin) levels of LF-Suo treated mice were lower, and SS (somatostatin), VIP (vasoactive intestinal peptide) levels were higher than the injured group mice. The cytokine IL-6 (interleukin 6), IL-12 (interleukin 12), TNF-alpha (tumor necrosis factor-alpha) and IFN-gamma (interferon-gamma) serum levels were decreased after the LF-Suo treatment. The gastric tissues SOD (superoxide dismutase), GSH-Px (glutathione peroxidase), NO (nitric oxide) and activities of LF-Suo treated mice were increased and MDA (malondialdehyde) activity was decreased compared to the injured group mice. By the RT-PCR assay, LF-Suo raised the occludin, EGF (epidermal growth factor), EGFR (epidermal growth factor receptor), VEGF (vascular endothelial growth factor), Fit-1 (fms-like tyrosine kinase-1), I kappa B-alpha (inhibitor kappaB-alpha), nNOS (neuronal nitric oxide synthase), eNOS (endothelial nitric oxide synthase), Mn-SOD, Cu/Zn-SOD, CAT (catalase) mRNA or protein expressions and reduced the COX-2, NF-kappa B (nuclear factor kappaB), and iNOS (inducible nitric oxide synthase) expressions in gastric tissues compared to the gastric injured group mice. A high concentration (1.0 x 10(9) CFU/kg b.w.) of LF-Suo treatment showed stronger anti-gastric injury effects compared to a low concentration of (0.5 x 10(9) CFU/kg b.w.) of LF-Suo treatment. LF-Suo also showed strong survival in pH 3.0 man-made gastric juice and hydrophobic properties. These results indicate that LF-Suo has potential use as probiotics for its gastric injury treatment effects.

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