Ochratoxin A Producing Fungi, Biosynthetic Pathway and Regulatory Mechanisms

文献类型： 外文期刊

第一作者： Wang, Yan

作者： Wang, Yan;Wang, Liuqing;Liu, Fei;Wang, Qi;Selvaraj, Jonathan Nimal;Xing, Fuguo;Zhao, Yueju;Liu, Yang;Wang, Yan;Xing, Fuguo;Zhao, Yueju;Liu, Yang

作者机构：

关键词： regulatory mechanisms;producing fungi;biosynthetic pathway;ochratoxin A

期刊名称：TOXINS （ 影响因子：4.546； 五年影响因子：4.8 ）

ISSN： 2072-6651

年卷期： 2016 年 8 卷 3 期

页码：

收录情况： SCI

摘要： Ochratoxin A (OTA), mainly produced by Aspergillus and Penicillum species, is one of the most important mycotoxin contaminants in agricultural products. It is detrimental to human health because of its nephrotoxicity, hepatotoxicity, carcinogenicity, teratogenicity, and immunosuppression. OTA structurally consists of adihydrocoumarin moiety linked with l-phenylalanine via an amide bond. OTA biosynthesis has been putatively hypothesized, although several contradictions exist on some processes of the biosynthetic pathway. We discuss recent information on molecular studies of OTA biosynthesis despite insufficient genetic background in detail. Accordingly, genetic regulation has also been explored with regard to the interaction between the regulators and the environmental factors. In this review, we focus on three aspects of OTA: OTA-producing strains, OTA biosynthetic pathway and the regulation mechanisms of OTA production. This can pave the way to assist in protecting food and feed from OTA contamination by understanding OTA biosynthetic pathway and regulatory mechanisms.

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