Protective efficacy of a recombinant Newcastle disease virus expressing glycoprotein of vesicular stomatitis virus in mice

文献类型： 外文期刊

第一作者： Zhang, Minmin

作者： Zhang, Minmin;Ge, Jinying;Li, Xiaofang;Chen, Weiye;Wang, Xijun;Wen, Zhiyuan;Bu, Zhigao

作者机构：

关键词： Vesicular stomatitis virus;Glycoprotein;Recombinant Newcastle disease virus;Vaccine

期刊名称：VIROLOGY JOURNAL （ 影响因子：4.099； 五年影响因子：3.719 ）

ISSN： 1743-422X

年卷期： 2016 年 13 卷

页码：

收录情况： SCI

摘要： Background: Vesicular stomatitis virus (VSV) causes severe losses to the animal husbandry industry. In this study, a recombinant Newcastle disease virus (NDV) expressing the glycoprotein (G) of VSV (rL-VSV-G) was constructed and its pathogenicity and immune protective efficacy in mouse were evaluated. Results: In pathogenicity evaluation test, the analysis of the viral distribution in mouse organs and body weight change showed that rL-VSV-G was safe in mice. In immune protection assay, the recombinant rL-VSV-G triggered a high titer of neutralizing antibodies against VSV. After challenge, the wild-type (wt) VSV viral load in mouse organs was lower in rL-VSV-G group than that in rLaSota groups. wt VSV was not detected in the blood, liver, or kidneys of mice, whereas it was found in these tissues in control groups. The mice body weight had no significant change after challenge in the rL-VSV-G group. Additionally, suckling mice produced from female mice immunized with rL-VSV-G were partially protected from wt VSV challenge. Conclusions: These results demonstrated that rL-VSV-G may be a suitable candidate vaccine against vesicular stomatitis (VS).

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