Foot-and-mouth disease virus non-structural protein 3A inhibits the interferon-beta signaling pathway

文献类型： 外文期刊

第一作者： Li, Dan

作者： Li, Dan;Yang, Fan;Liu, Huanan;Zhu, Zixiang;Liu, Xiangtao;Zheng, Haixue;Lei, Caoqi;Xu, Zhisheng;Li, Shu;Shu, Hongbing

作者机构：

期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.379； 五年影响因子：5.133 ）

ISSN： 2045-2322

年卷期： 2016 年 6 卷

页码：

收录情况： SCI

摘要： Foot-and-mouth disease virus (FMDV) is the etiological agent of FMD, which affects cloven-hoofed animals. The pathophysiology of FMDV has not been fully understood and the evasion of host innate immune system is still unclear. Here, the FMDV non-structural protein 3A was identified as a negative regulator of virus-triggered IFN-beta signaling pathway. Overexpression of the FMDV 3A inhibited Sendai virus-triggered activation of IRF3 and the expressions of RIG-I/MDA5. Transient transfection and co-immunoprecipitation experiments suggested that FMDV 3A interacts with RIG-I, MDA5 and VISA, which is dependent on the N-terminal 51 amino acids of 3A. Furthermore, 3A also inhibited the expressions of RIG-I, MDA5, and VISA by disrupting their mRNA levels. These results demonstrated that 3A inhibits the RLR-mediated IFN-beta induction and uncovered a novel mechanism by which the FMDV 3A protein evades the host innate immune system.

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