Hyaluronic acid-functionalized redox-responsive organosilica nanoparticles for targeted resveratrol delivery to attenuate acrylamide-induced toxicity

文献类型： 外文期刊

第一作者： Jiang, Dan

作者： Jiang, Dan;Xia, Xiaoyang;He, Zhixiong;Xiang, Xia;Jiang, Dan;He, Zhixiong;Xue, Yanan

作者机构：

关键词： Acrylamide toxicity; Organosilica; Resveratrol; Hyaluronic acid; Redox-responsive release

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.2； 五年影响因子：7.8 ）

ISSN： 0141-8130

年卷期： 2023 年 232 卷

页码：

收录情况： SCI

摘要： The purpose of this study is to construct a redox-responsive and targeted nanoparticle to effectively deliver resveratrol (Res) for alleviating acrylamide (ACR) toxicity. Here, Res-loaded tetrasulfide-containing organosilica nanoparticles (DSMSNs) functionalized with hyaluronic acid on the surface (DSMSNs@Res@HA) were prepared. The DSMSNs@Res@HA nanoparticles were spherical with an encapsulation efficiency of 46.68 +/- 1.64 % and a hydrated particle size of about 237.73 nm. As expected, DSMSNs@Res@HA were capable of significantly protecting PC12 cells against ACR-induced damage in oxidative stress, mitochondrial membrane potential decrease, and cell apoptosis compared with free Res and DSMSNs@Res at the equivalent dose. Moreover, DSMSNs@Res@HA could be biodegraded and released Res in response to GSH stimulus. In vivo experiments suggested that DSMSNs@Res@HA significantly reduced histological damage in the brain, liver, and kidney of rats compared with free Res and DSMSNs@Res. After oral administration of DSMSNs@Res@HA, the intestinal flora of ACRtreated rats could be effectively regulated by improving the species uniformity and abundance as well as recovering the species diversity. According to these findings, DSMSNs@Res@HA is worth further investigation as a potential therapeutic nanomedicine to alleviate ACR toxicity and restore gut microbiota diversity.

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