Characterization and Uncertainty Assessment of a Certified Reference Material of Chloramphenicol in Methanol (GBW(E)082557)

文献类型： 外文期刊

第一作者： Yang, Mengrui

作者： Yang, Mengrui;Wang, Min;Zhou, Jian;Song, Yinqing;Wang, Tongtong

作者机构：

期刊名称：INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY （ 影响因子：1.885； 五年影响因子：2.52 ）

ISSN： 1687-8760

年卷期： 2016 年

页码：

收录情况： SCI

摘要： Prior to preparation of CRM candidate of chloramphenicol in methanol with a concentration of 100 mg/L, two independent methods including mass balance (MB) and quantitative nuclear magnetic resonance (qNMR) were employed to precisely measure the mass fraction of pure chloramphenicol materials. The mass fraction was assigned to be 99.8% with uncertainty of 0.3%. Homogeneity testing and stability study of chloramphenicol in methanol were examined by using high performance liquid chromatography. Additionally, the uncertainties originating from the process of CRM development were comprehensively evaluated. The experimental results indicate that the property value of this CRM is homogeneous and stable at 4 degrees C for at least six months. The new CRM (GBW(E)082557) can be applicable to calibration of instrument and assurance of accuracy and comparability of results in routine measurement.

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