Characterization of a nonhemagglutinating mutant of mink enteritis virus in China

文献类型: 外文期刊

第一作者: Tan, Bin

作者: Tan, Bin;Zhang, Shu-Qin;Wang, Jian-Ke;Zhao, Hang;Chen, Li-Zhi;Wu, Wei;Cheng, Shi-Peng

作者机构:

关键词: MEV;hemagglutination;amino acids

期刊名称:INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE ( 影响因子:0.166; 五年影响因子:0.621 )

ISSN: 1940-5901

年卷期: 2016 年 9 卷 2 期

页码:

收录情况: SCI

摘要: Parvoviruses are small eukaryotic DNA viruses that infect a variety of animal species, including humans. Canine parvovirus type-2, feline panleukopenia virus and mink enteritis virus are all host-range variants of the carnivore parvovirus subgroup. These viruses could hema lutinate (HA) swine or rhesus monkey erythrocytes in buffered saline solutions at pHs between 6.0 and 6.8. Here we report a nonhema Iutinating mutant of MEV and the amino acid differences compared with other MEV, FPV and CPV strains. Further studies and investigations on MEV are needed to clarify whether this mutant is fixed in the MEV population as a consequence of the mechanisms of antigenic escape or further adaptation to broader host range. It turns crucial to have a better understanding of the epidemiology and evolution of parvovirus.

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